生物胶粘剂在生物医学中的应用综述

IF 3.5 Q2 Materials Science

Reviews of Adhesion and Adhesives Pub Date : 2020-06-30 DOI:10.7569/raa.2020.097308

A. Dey, Proma Bhattacharya, S. Neogi

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引用次数: 2

摘要

药物与粘液层/上皮细胞或两者的组合之间需要长时间接触，这需要生物粘附剂。已知一种生物粘合剂可以加强两者之间的接触，并有助于药物的控制释放。已知常规使用的生物粘合剂具有较差的粘附强度并且可能具有毒性副作用。这篇综述的重点是用作生物粘合剂的各种类型的聚合物及其复合材料，它们可以克服前面提到的问题。其中包括一些天然存在的生物粘合剂，如胶原蛋白、壳聚糖、白蛋白、右旋糖酐，以及一些合成生物粘合剂，例如明胶、聚乙二醇、丙烯酸、乳酸-乙醇酸基生物粘合剂。临床试验证明了这些生物粘合剂的有效性，发现它们比商业胶水更有效，因此在生物医学工业中具有巨大的应用潜力。

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Bioadhesives in Biomedical Applications: A Critical Review

The necessity for a long time contact between the drug and mucus layer/epithelial cell or a combination of the two requires a bioadhesive. A bioadhesive is known to intensify contact between the two and help in controlled release of drugs. The conventionally used bioadhesives are known to have poor adhesion strength and can have toxic side effects. This review focuses on the various types of polymers and their composites for use as bioadhesives which can overcome the previously mentioned issues. These include some naturally occurring bioadhesives such as collagen, chitosan, albumin, dextran and some synthetic bioadhesives like gelatin, poly(ethylene glycol), poly(acrylic acid), poly(lactic-co-glycolic acid) based bioadhesives. The clinical trials prove the effectiveness of these bioadhesives and they are found to be more efficient than the commercial glues and hence possess great potential for use in the biomedical industry.

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来源期刊

Reviews of Adhesion and Adhesives MATERIALS SCIENCE, MULTIDISCIPLINARY-

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期刊介绍： With the explosion of research activity and reports, the need for concise and critical reviews of topics of contemporary research interest is manifest. Reviews of Adhesion and Adhesives (RAA) provides in-depth, incisive, illuminating and thought-provoking reviews written by subject matter experts covering all aspects of adhesion science and adhesive technology. Each review will be imbued with the author’s experience so that the reader will be able to assimilate the research in the area discussed easily and will be able to apply it in practice.The journal has relevance to a myriad of industries including textiles, printing, coatings, aerospace, medical, nanotechnology, biotechnology, building and construction, and microelectronics. The topics to be covered include, but not limited to, basic and theoretical aspects of adhesion; modeling of adhesion phenomena; mecha¬nisms of adhesion; surface and interfacial analysis and characterization; unraveling of events at interfaces; characterization of interphases; adhesion of thin films and coatings; adhesion aspects in reinforced composites; formation, characterization and durability of adhesive joints; surface preparation methods; polymer surface modification; biological adhesion; particle adhesion; adhesion of metallized plastics; adhesion of diamond-like films; adhesion pro¬moters; contact angle, wettability· and adhesion; superhydrophobicity and superhydrophilicity. With regard to adhesives, RAA will include, but not limited to, green adhesives; novel and high-performance adhesives; and medical adhesive applications.