动脉血栓形成:COVID-19大流行受害者的隐晦威胁

IF 0.2 Q4 PERIPHERAL VASCULAR DISEASE
B. Boneva, Margaret P. Dimova, N. Nikolov, Boyka I. Stoyanova, Boris N. Ilchev
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引用次数: 0

摘要

简介:SARS-CoV-2是一种新型冠状病毒,是当前全球大流行的罪魁祸首,导致全球病例和死亡人数不断上升。关于因所有动脉床血栓形成而出现急性肢体缺血的患者,越来越多的报道。我们进行了一项文献综述,以确定和总结有关新冠肺炎诱导的急性外周动脉血栓形成的发病率、潜在的病理生理机制、临床表现、诊断、手术结果和肢体挽救结果的可用数据。证据获取:本综述的参考文献是通过2019年12月1日至2021年3月15日在PubMed、Ovid Medline和Embase上使用与新冠肺炎相关的相关术语进行搜索确定的。还搜索了这些文章的参考文献列表。36篇出版物被认为与本文献综述相关。证据综合:应进行积极及时的药物治疗和手术干预,以获得积极的治疗结果。然而,缺乏循证协议仍然是医疗保健提供者面临的障碍。需要对SARS-CoV-2感染进行进一步的高质量研究,重点关注动脉血栓形成并发症,以确定冠状病毒对动脉的影响,并评估新冠肺炎外周动脉闭塞性疾病或血栓形成倾向性患者进行治疗性抗凝的必要性。结论:医疗保健提供者应意识到新冠肺炎的表现,并应保持较高的怀疑指数,以便所有人都能从已发现有效措施的证据中受益。尽管之前的报告也确定了新冠肺炎肢体缺血患者,但关于临床过程和治疗的数据有限。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Arterial thrombosis: the obscure threat in COVID-19 pandemic victims
INTRODUCTION: SARS-CoV-2 is a novel Coronavirus responsible for the current global pandemic resulting in an escalating number of cases and fatalities worldwide. There is a growing number of reports regarding patients presenting with acute limb ischemia due to thrombosis of all arterial beds. We conducted a literature review to identify and summarize the available data regarding the incidence of COVID-19 induced acute peripheral arterial thrombosis, potential pathophysiological mechanisms, clinical representation, diagnosis, surgical outcomes and limb salvage results. EVIDENCE ACQUISITION: References for this review were identified through searches on PubMed, Ovid Medline, and Embase from December 1, 2019 to March 15, 2021 using relevant terms related to COVID-19. Reference lists of the articles were also searched. Thirty-six publications were deemed relevant for the purpose of this literature review. EVIDENCE SYNTHESIS: An aggressive and timely medical therapy and surgical interventions should be performed to obtain positive treatment outcomes. Nevertheless, the absence of evidence-based protocols remains an obstacle for healthcare providers. Further quality research about SARS-CoV-2 infection with a focus on arterial thrombotic complications are needed to characterize arterial consequences of Coronavirus and to evaluate the necessity of therapeutic anticoagulation in COVID-19 patients with peripheral arterial occlusive disease or thrombophilia. CONCLUSIONS: Healthcare providers should be aware of the manifestations of COVID-19 and a high index of suspicion should be maintained so that all can benefit from evidence of measures that have been found to be effective. Although previous reports also identified COVID-19 patients with limb ischemia, there is limited data on the clinical course and treatment.
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来源期刊
CiteScore
1.00
自引率
0.00%
发文量
27
审稿时长
>12 weeks
期刊介绍: The Italian Journal of Vascular and Endovascular Surgery publishes scientific papers on vascular surgery. Manuscripts may be submitted in the form of editorials, original articles, review articles, case reports, therapeutical notes, special articles and letters to the Editor.
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