B. Boneva, Margaret P. Dimova, N. Nikolov, Boyka I. Stoyanova, Boris N. Ilchev
{"title":"动脉血栓形成:COVID-19大流行受害者的隐晦威胁","authors":"B. Boneva, Margaret P. Dimova, N. Nikolov, Boyka I. Stoyanova, Boris N. Ilchev","doi":"10.23736/s1824-4777.21.01509-6","DOIUrl":null,"url":null,"abstract":"INTRODUCTION: SARS-CoV-2 is a novel Coronavirus responsible for the current global pandemic resulting in an escalating number of cases and fatalities worldwide. There is a growing number of reports regarding patients presenting with acute limb ischemia due to thrombosis of all arterial beds. We conducted a literature review to identify and summarize the available data regarding the incidence of COVID-19 induced acute peripheral arterial thrombosis, potential pathophysiological mechanisms, clinical representation, diagnosis, surgical outcomes and limb salvage results. EVIDENCE ACQUISITION: References for this review were identified through searches on PubMed, Ovid Medline, and Embase from December 1, 2019 to March 15, 2021 using relevant terms related to COVID-19. Reference lists of the articles were also searched. Thirty-six publications were deemed relevant for the purpose of this literature review. EVIDENCE SYNTHESIS: An aggressive and timely medical therapy and surgical interventions should be performed to obtain positive treatment outcomes. Nevertheless, the absence of evidence-based protocols remains an obstacle for healthcare providers. Further quality research about SARS-CoV-2 infection with a focus on arterial thrombotic complications are needed to characterize arterial consequences of Coronavirus and to evaluate the necessity of therapeutic anticoagulation in COVID-19 patients with peripheral arterial occlusive disease or thrombophilia. CONCLUSIONS: Healthcare providers should be aware of the manifestations of COVID-19 and a high index of suspicion should be maintained so that all can benefit from evidence of measures that have been found to be effective. Although previous reports also identified COVID-19 patients with limb ischemia, there is limited data on the clinical course and treatment.","PeriodicalId":54914,"journal":{"name":"Italian Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":0.2000,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Arterial thrombosis: the obscure threat in COVID-19 pandemic victims\",\"authors\":\"B. Boneva, Margaret P. Dimova, N. Nikolov, Boyka I. Stoyanova, Boris N. Ilchev\",\"doi\":\"10.23736/s1824-4777.21.01509-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"INTRODUCTION: SARS-CoV-2 is a novel Coronavirus responsible for the current global pandemic resulting in an escalating number of cases and fatalities worldwide. There is a growing number of reports regarding patients presenting with acute limb ischemia due to thrombosis of all arterial beds. We conducted a literature review to identify and summarize the available data regarding the incidence of COVID-19 induced acute peripheral arterial thrombosis, potential pathophysiological mechanisms, clinical representation, diagnosis, surgical outcomes and limb salvage results. EVIDENCE ACQUISITION: References for this review were identified through searches on PubMed, Ovid Medline, and Embase from December 1, 2019 to March 15, 2021 using relevant terms related to COVID-19. Reference lists of the articles were also searched. Thirty-six publications were deemed relevant for the purpose of this literature review. EVIDENCE SYNTHESIS: An aggressive and timely medical therapy and surgical interventions should be performed to obtain positive treatment outcomes. Nevertheless, the absence of evidence-based protocols remains an obstacle for healthcare providers. Further quality research about SARS-CoV-2 infection with a focus on arterial thrombotic complications are needed to characterize arterial consequences of Coronavirus and to evaluate the necessity of therapeutic anticoagulation in COVID-19 patients with peripheral arterial occlusive disease or thrombophilia. CONCLUSIONS: Healthcare providers should be aware of the manifestations of COVID-19 and a high index of suspicion should be maintained so that all can benefit from evidence of measures that have been found to be effective. Although previous reports also identified COVID-19 patients with limb ischemia, there is limited data on the clinical course and treatment.\",\"PeriodicalId\":54914,\"journal\":{\"name\":\"Italian Journal of Vascular and Endovascular Surgery\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2021-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Italian Journal of Vascular and Endovascular Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.23736/s1824-4777.21.01509-6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PERIPHERAL VASCULAR DISEASE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Italian Journal of Vascular and Endovascular Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23736/s1824-4777.21.01509-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
Arterial thrombosis: the obscure threat in COVID-19 pandemic victims
INTRODUCTION: SARS-CoV-2 is a novel Coronavirus responsible for the current global pandemic resulting in an escalating number of cases and fatalities worldwide. There is a growing number of reports regarding patients presenting with acute limb ischemia due to thrombosis of all arterial beds. We conducted a literature review to identify and summarize the available data regarding the incidence of COVID-19 induced acute peripheral arterial thrombosis, potential pathophysiological mechanisms, clinical representation, diagnosis, surgical outcomes and limb salvage results. EVIDENCE ACQUISITION: References for this review were identified through searches on PubMed, Ovid Medline, and Embase from December 1, 2019 to March 15, 2021 using relevant terms related to COVID-19. Reference lists of the articles were also searched. Thirty-six publications were deemed relevant for the purpose of this literature review. EVIDENCE SYNTHESIS: An aggressive and timely medical therapy and surgical interventions should be performed to obtain positive treatment outcomes. Nevertheless, the absence of evidence-based protocols remains an obstacle for healthcare providers. Further quality research about SARS-CoV-2 infection with a focus on arterial thrombotic complications are needed to characterize arterial consequences of Coronavirus and to evaluate the necessity of therapeutic anticoagulation in COVID-19 patients with peripheral arterial occlusive disease or thrombophilia. CONCLUSIONS: Healthcare providers should be aware of the manifestations of COVID-19 and a high index of suspicion should be maintained so that all can benefit from evidence of measures that have been found to be effective. Although previous reports also identified COVID-19 patients with limb ischemia, there is limited data on the clinical course and treatment.
期刊介绍:
The Italian Journal of Vascular and Endovascular Surgery publishes scientific papers on vascular surgery. Manuscripts may be submitted in the form of editorials, original articles, review articles, case reports, therapeutical notes, special articles and letters to the Editor.