{"title":"达泊西汀对慢性收缩性损伤(CCI)大鼠神经痛的影响","authors":"Akram Zare Bidakia, Mohsen Zabihib, Mohadeseh Asadic, Reza Bidakid","doi":"10.37897/rjn.2022.1.6","DOIUrl":null,"url":null,"abstract":"Introduction. Recent studies have shown that SSRIs have anti-inflammatory effects, and their administration prevents their production by acting on inflammatory cytokines. Emphasizing that we did not find a study on Dapoxetine and its effect on neuropathic pain, in this study, we examined the effect of Dapoxetine on neuropathic pain in rats. Material and methods. 42 rats were divided into six groups of 7, which included: sham, control, gabapentin, Duloxetine and Dapoxetine 1 and 3. Except for the sham group, other groups were induced with neuropathy, and no drug treatment was performed in the sham group. The groups were treated with normal saline, gabapentin (30 mg/kg/day), Duloxetine at (30 mg/kg/day) and Dapoxetine (1 and 3 mg/kg/day), respectively by intraperitoneal injection. Then, thermal hyperalgesia and mechanical and thermal allodynia experiments were performed on rats. Results. The Dapoxetine-treated groups’ mean response to thermal hyperalgesia and mechanical allodynia increased on days 7 and 14. The mean response of the 3 mg/kg Dapoxetine group on day 7 was significantly higher than the control group (P <0.05). Mean response to mechanical and thermal allodynia-induced stimulation and thermal hyperactivity in the Dapoxetine group 3 mg/kg at 14 days, compared with the Dapoxetine group 1 mg/kg showed significantly better results (P <0.05). Conclusion. Dapoxetine effectively reduces the behavioral response to painful and non-painful thermal and mechanical stimuli and painful thermal and mechanical stimuli. In addition to its short-term analgesic effects, it also has long-term effects.","PeriodicalId":37662,"journal":{"name":"Romanian Journal of Neurology/ Revista Romana de Neurologie","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effect of Dapoxetine on Chronic Constriction Injury (CCI) induced neuralgia in rats\",\"authors\":\"Akram Zare Bidakia, Mohsen Zabihib, Mohadeseh Asadic, Reza Bidakid\",\"doi\":\"10.37897/rjn.2022.1.6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction. Recent studies have shown that SSRIs have anti-inflammatory effects, and their administration prevents their production by acting on inflammatory cytokines. Emphasizing that we did not find a study on Dapoxetine and its effect on neuropathic pain, in this study, we examined the effect of Dapoxetine on neuropathic pain in rats. Material and methods. 42 rats were divided into six groups of 7, which included: sham, control, gabapentin, Duloxetine and Dapoxetine 1 and 3. Except for the sham group, other groups were induced with neuropathy, and no drug treatment was performed in the sham group. The groups were treated with normal saline, gabapentin (30 mg/kg/day), Duloxetine at (30 mg/kg/day) and Dapoxetine (1 and 3 mg/kg/day), respectively by intraperitoneal injection. Then, thermal hyperalgesia and mechanical and thermal allodynia experiments were performed on rats. Results. The Dapoxetine-treated groups’ mean response to thermal hyperalgesia and mechanical allodynia increased on days 7 and 14. The mean response of the 3 mg/kg Dapoxetine group on day 7 was significantly higher than the control group (P <0.05). Mean response to mechanical and thermal allodynia-induced stimulation and thermal hyperactivity in the Dapoxetine group 3 mg/kg at 14 days, compared with the Dapoxetine group 1 mg/kg showed significantly better results (P <0.05). Conclusion. Dapoxetine effectively reduces the behavioral response to painful and non-painful thermal and mechanical stimuli and painful thermal and mechanical stimuli. In addition to its short-term analgesic effects, it also has long-term effects.\",\"PeriodicalId\":37662,\"journal\":{\"name\":\"Romanian Journal of Neurology/ Revista Romana de Neurologie\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-03-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Romanian Journal of Neurology/ Revista Romana de Neurologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37897/rjn.2022.1.6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Romanian Journal of Neurology/ Revista Romana de Neurologie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37897/rjn.2022.1.6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
The effect of Dapoxetine on Chronic Constriction Injury (CCI) induced neuralgia in rats
Introduction. Recent studies have shown that SSRIs have anti-inflammatory effects, and their administration prevents their production by acting on inflammatory cytokines. Emphasizing that we did not find a study on Dapoxetine and its effect on neuropathic pain, in this study, we examined the effect of Dapoxetine on neuropathic pain in rats. Material and methods. 42 rats were divided into six groups of 7, which included: sham, control, gabapentin, Duloxetine and Dapoxetine 1 and 3. Except for the sham group, other groups were induced with neuropathy, and no drug treatment was performed in the sham group. The groups were treated with normal saline, gabapentin (30 mg/kg/day), Duloxetine at (30 mg/kg/day) and Dapoxetine (1 and 3 mg/kg/day), respectively by intraperitoneal injection. Then, thermal hyperalgesia and mechanical and thermal allodynia experiments were performed on rats. Results. The Dapoxetine-treated groups’ mean response to thermal hyperalgesia and mechanical allodynia increased on days 7 and 14. The mean response of the 3 mg/kg Dapoxetine group on day 7 was significantly higher than the control group (P <0.05). Mean response to mechanical and thermal allodynia-induced stimulation and thermal hyperactivity in the Dapoxetine group 3 mg/kg at 14 days, compared with the Dapoxetine group 1 mg/kg showed significantly better results (P <0.05). Conclusion. Dapoxetine effectively reduces the behavioral response to painful and non-painful thermal and mechanical stimuli and painful thermal and mechanical stimuli. In addition to its short-term analgesic effects, it also has long-term effects.
期刊介绍:
ROMANIAN JOURNAL OF NEUROLOGY (Revista Română de Neurologie), the official journal of the Romanian Society of Neurology, was founded in 2001, being a prestigious scientific journal that provides a high quality in terms of scientific content, but also the editorial and graphic aspect, both through an impartial process of selection, evaluation and correction of articles (peer review procedure), as well as providing editorial, graphic and printing conditions at the highest level. In order to increase the scientific standards of the journal, special attention was paid to the improvement of the quality of the published materials. Guidance articles, clinical trials and case studies are structured in several sections: reviews, original articles, case reports, images in neurology. All articles are published entirely in English. A team of reputable medical professionals in the field of neurology is involved in a rigorous peer review process that complies with international ethics and quality rules in the academic world.