短合成肽作为具有抗增殖活性的Cox-2抑制剂:可能的未来一类药物

Q2 Pharmacology, Toxicology and Pharmaceutics
Jun Moni Kalita, Fazid Ali, Momitul Ahmed, Sushankar Kushari, Zartaj Washmin Banu, Damiki Laloo
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引用次数: 0

摘要

癌症仍然是世界范围内死亡的主要原因,传统的化学疗法会产生严重的副作用。由于其独特的特性,包括选择性、稳定性和生物相容性,短合成肽已成为潜在的替代品。最近的研究表明,短肽可以通过抑制COX-2(环氧化酶-2)酶作为有效的抗癌药物,COX-2是参与肿瘤生长和进展的关键酶。特别是,短肽在靶向肿瘤微环境、破坏血管生成和诱导癌细胞凋亡方面显示出良好的效果。本文综述了短肽作为抗癌药物的研究现状,包括其作用机制和未来的研究发展方向。结果表明,短肽作为一类新的抗癌药物具有巨大的潜力,值得进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Short Synthetic Peptides as Cox-2 Inhibitor with Antiproliferative Activity: A Probable Future Class of Drugs
Cancer remains a leading cause of death worldwide, with traditional chemotherapy treatments causing significant side effects. Short synthetic peptides have emerged as a potential alternative due to their unique properties, including selectivity, stability and biocompatibility. Recent research has shown that short peptides can act as effective anticancer agents through their ability to inhibit the COX-2 (Cyclooxegenase-2) enzyme, a key enzyme involved in tumor growth and progression. In particular, short peptides have demonstrated promising results in targeting the tumor microenvironment, disrupting angiogenesis, and inducing apoptosis in cancer cells. This review summarizes the current literature on short peptides as anticancer agents, including their mechanisms of action and future directions for research and development. The results suggest that short peptides hold significant potential as a new class of anticancer agents and warrant further investigation.
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来源期刊
Current Bioactive Compounds
Current Bioactive Compounds Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.90
自引率
0.00%
发文量
112
期刊介绍: The journal aims to provide comprehensive review articles on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia. The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.
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