将药物接枝到功能化的单壁碳纳米管上作为一种潜在的药物递送方法

IF 1.4 Q3 CHEMISTRY, MULTIDISCIPLINARY

Physical Chemistry Research Pub Date : 2021-03-01 DOI:10.22036/PCR.2020.232018.1775

Maryam Heidarian, A. Khazaei, J. Saien

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引用次数: 2

摘要

将美沙拉秦和氟伏沙明药物接枝到单壁碳纳米管（SWCNTs）上，以达到精确给药的目的。首先，SWCNT中的羧基被转化为相应的酰氯。接下来，为了形成酰胺键，将酰氯SWCNT与具有NH2和NH官能团的化学治疗剂混合。然后，通过紫外-可见光谱、红外光谱和透射电子显微镜（TEM）等方法对药物与单壁碳纳米管的共价接枝进行了表征。最后，将制备的有机化合物用于在pH:1.3下释放药物，这与人体的临床方面相对应，并检查了在患者中给药的潜力。因此，对药物的体外动力学和释放机制进行了研究。

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Grafting Drugs to Functionalized Single-wall Carbon Nanotubes as a Potential Method for Drug Delivery

The mesalazine and fluvoxamine drugs were grafted to single-walled carbon nanotubes (SWCNTs) for the aim of precise drug delivery. First, carboxylic groups in SWCNT were converted to corresponding acyl chlorides. Next, to attain the formation of amide bonds, acyl chloride-SWCNTs were mixed with chemotherapeutic agents, having NH2 and NH functional groups. Then, the covalently grafted drugs to SWCNT were characterized by UV- visible, IR spectroscopy, and transmission electron microscopy (TEM) methods. Finally, the prepared organic compounds were used for releasing drugs at pH: 1.3, which is corresponding to clinical aspects of the human body, and were examined for the potential of drug delivery in patients. Accordingly, the in-vitro kinetic as well as the mechanism of the released drugs were investigated.

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来源期刊

Physical Chemistry Research CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

2.70

自引率

8.30%

发文量

期刊介绍： The motivation for this new journal is the tremendous increasing of useful articles in the field of Physical Chemistry and the related subjects in recent years, and the need of communication between Physical Chemists, Physicists and Biophysicists. We attempt to establish this fruitful communication and quick publication. High quality original papers in English dealing with experimental, theoretical and applied research related to physics and chemistry are welcomed. This journal accepts your report for publication as a regular article, review, and Letter. Review articles discussing specific areas of physical chemistry of current chemical or physical importance are also published. Subjects of Interest: Thermodynamics, Statistical Mechanics, Statistical Thermodynamics, Molecular Spectroscopy, Quantum Chemistry, Computational Chemistry, Physical Chemistry of Life Sciences, Surface Chemistry, Catalysis, Physical Chemistry of Electrochemistry, Kinetics, Nanochemistry and Nanophysics, Liquid Crystals, Ionic Liquid, Photochemistry, Experimental article of Physical chemistry. Mathematical Chemistry.