亚麻籽预防干扰素α诱导的小鼠抑郁行为:α-亚麻酸是必需的

IF 1.1 Q4 PHARMACOLOGY & PHARMACY
A. Mesripour, M. Almasi
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引用次数: 3

摘要

背景和目的:干扰素-α(IFN-α)是一种具有多种临床应用的细胞因子,但它可能通过降低色氨酸水平和产生神经活性代谢产物来诱导抑郁症。由于亚麻籽是氨基酸、α-亚麻酸(ALA)和木脂素的宝贵来源,可以预防炎症和神经毒性,因此评估了亚麻籽对IFN-α诱导的抑制剂的影响。方法:采用整粒亚麻籽在小鼠日粮中施用亚麻籽,或采用管饲法施用亚麻籽油,直至观察到有效的抗抑郁作用。78只雄性白化小鼠,25±3g,分为13组,注射IFN-α16×105IU/kg,持续6天。运动测试后,强迫游泳测试(FST)用于测量指示绝望行为的静止时间,蔗糖偏好测试用于测量快感缺乏。结果:两组患者的运动能力差异不大;然而,IFN-α使静止时间增加(154.5±11.22s,对照组为121.3±7.14s;p=0.031),蔗糖偏好为65%,表明抑郁。与IFN-α正常饮食相比,30%的亚麻籽或25%的亚麻籽油与IFN-γ联合给药显著缩短了静止时间(分别为92.67±11.60 s和94.17±10.12 s,p<0.01),蔗糖偏好也增加,这支持了抗抑郁作用。结论:亚麻籽能抑制IFN-α诱导的小鼠抑郁样行为。尽管从动物到人类的研究需要仔细解读,但这项研究支持在饮食中使用亚麻籽作为预防高危人群抑郁的合理策略,例如接受IFN-α治疗的患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Flaxseed Prevents Interferon-alpha Induced Depressive Behavior in Mice: the α-Linolenic Acid is Essential
Background and objectives: Interferon-alpha (IFN-α) is a cytokine with various clinical applications, but it may induce depression by decreasing tryptophan level and producing neuroactive metabolites. Since Linum usitatissimum (flaxseed) is a valuable source for amino acids, α-linolenic acid (ALA), and lignans that could prevent inflammation and neurotoxicity, flaxseed effects on IFN-α induced depressant was evaluated. Methods: Flaxseed was applied either by whole ground flaxseeds in mice diet, or flaxseed oil by gavage feeding tube until effective antidepressant effects were observed. Seventy-eight male albino mice 25±3 g were used and divided in 13 groups, IFN-α 16×10 5 IU/kg was injected for 6 days. After the locomotor test, the forced swimming test (FST) was used to measure the immobility time indicating despair behavior, and the sucrose preference test measured anhedonia. Results: There were only marginal differences in the locomotor activity; however, the immobility time increased by IFN-α (154.5±11.22 s, vs control 121.3±7.14 s; p=0.031), and sucrose preference was 65% indicating depression. The administration of flaxseed 30% or flaxseed oil 25% with IFN-α significantly reduced the immobility time (92.67±11.60 s and 94.17±10.12 s, respectively, vs IFN-α normal diet, p<0.01), sucrose preference also increased that supported the antidepressant effect. Conclusion: Flaxseed could prevent IFN-α induced depressive-like behavior in mice. Although interpretation from animal to human studies needs careful attention, this study supports the use of flaxseed in the diet as reasonable strategy to prevent depression in high-risk individuals, such as patients treated with IFN-α.
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来源期刊
Research Journal of Pharmacognosy
Research Journal of Pharmacognosy PHARMACOLOGY & PHARMACY-
CiteScore
1.10
自引率
20.00%
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0
审稿时长
8 weeks
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