有机催化立体选择性糖基化:近十年的综述

IF 1.9 4区 化学 Q2 CHEMISTRY, ORGANIC
C. A. de Parrodi, Mildred López, Gabriela Huelgas, J. D. Lozada-Ramírez
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引用次数: 0

摘要

尽管低聚糖的合成已经有了重要的发展,但通过无毒、温和和廉价的技术高效和立体选择性地研究糖苷键是有机合成中最具挑战性的领域之一。糖基反应在生物材料和结构-活性关系中起着重要作用,具有许多药物化学应用。为此,多年来已经发展出一些有趣的策略来控制糖苷键的立体选择性,包括操纵不同的反应元素,主要是促进剂或催化剂,但也涉及给体和溶剂的性质。这篇综述着眼于糖基化方法在过去的十年中导致α或β糖苷键的特定形成。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Organocatalyzed stereoselective glycosylation: an overview of the last decade
Even though there has been an important evolution in the synthesis of oligosaccharides, the efficient and stereoselective study of glycosidic bonds through non-toxic, moderate, and inexpensive techniques is one of the most challenging fields in organic synthesis. Glycosyl reactions play a fundamental role in biological material and structure-activity relationships, having numerous medicinal chemistry applications. For this, interesting strategies have evolved over the years to control the stereoselectivity of glycosidic bonds, including the manipulation of different reaction elements, mainly promoters or catalysts, but also involving the nature of donors and solvents. This review looks at glycosylation methodologies in the last decade resulting in the specific formation of alpha or beta glycosidic bonds.
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来源期刊
Mini-reviews in Organic Chemistry
Mini-reviews in Organic Chemistry 化学-有机化学
CiteScore
4.50
自引率
4.30%
发文量
116
审稿时长
>12 weeks
期刊介绍: Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry
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