C. A. de Parrodi, Mildred López, Gabriela Huelgas, J. D. Lozada-Ramírez
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Organocatalyzed stereoselective glycosylation: an overview of the last decade
Even though there has been an important evolution in the synthesis of oligosaccharides, the efficient and stereoselective study of glycosidic bonds through non-toxic, moderate, and inexpensive techniques is one of the most challenging fields in organic synthesis. Glycosyl reactions play a fundamental role in biological material and structure-activity relationships, having numerous medicinal chemistry applications. For this, interesting strategies have evolved over the years to control the stereoselectivity of glycosidic bonds, including the manipulation of different reaction elements, mainly promoters or catalysts, but also involving the nature of donors and solvents. This review looks at glycosylation methodologies in the last decade resulting in the specific formation of alpha or beta glycosidic bonds.
期刊介绍:
Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges.
The journal encourages submission of reviews on emerging fields of organic chemistry including:
Bioorganic Chemistry
Carbohydrate Chemistry
Chemical Biology
Chemical Process Research
Computational Organic Chemistry
Development of Synthetic Methodologies
Functional Organic Materials
Heterocyclic Chemistry
Macromolecular Chemistry
Natural Products Isolation And Synthesis
New Synthetic Methodology
Organic Reactions
Organocatalysis
Organometallic Chemistry
Theoretical Organic Chemistry
Polymer Chemistry
Stereochemistry
Structural Investigations
Supramolecular Chemistry