Analysis of genome wide associated variants rs2651899 (PRDM16), rs11172113 (LRP1), and rs10166942 (TRPM8) of migraine in the Indian episodic migraineurs

Background: The involvement of genes in migraine pain is identified by several studies. Many genome-wide association studies (GWAS) revealed the presence of particular variants in different migraine populations worldwide. Objective: This study aims in analyzing the presence of 3 GWAS variants (rs2651899 [PRDM16], rs11172113 [LRP1], and rs10166942 Transient Receptor Potential Cation Channel Subfamily M Member 8 [TRPM8]) in the Indian episodic migraineurs. Methodology: Enrolled 200 age- and gender-matched patients and control volunteers; collected blood samples to isolate DNA to check the presence of chosen variants in them. The results obtained were statistically analyzed using SPSS version 26.0. Results: The rs10166942 (TRPM8) variant is observed in 1.5% of control, 15.88% of migraine with aura, and 5.37% of migraine without aura subjects with the highly significant P < 0.0008. The other two variants are absent in the chosen sample group. Conclusion: We reported the presence of rs10166942 in the Indian episodic migraineurs and we recommend pathway analysis for confirming its association with the migraine pain progression.