血清Hcy诊断糖尿病肾病的荟萃分析

IF 0.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Pteridines Pub Date : 2020-01-01 DOI:10.1515/pteridines-2020-0001

Xiaoling Zhou, Aijie Shi, Xiaoping Zhou

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引用次数: 2

摘要

摘要目的本荟萃分析旨在探讨血清同型半胱氨酸（Hcy）作为糖尿病肾病（DN）生物标志物的诊断性能。方法系统检索与血清Hcy水平和DN相关的临床文献；Pubmed、Cochrane Library、Embase、Web of science、CNKI和CBM。从每个纳入的原始研究中提取诊断数据，并根据诊断灵敏度、特异性、阳性可能胡德比（+LR）、阴性可能胡德比率（-LR）、诊断优势比（DOR）和对称ROC曲线下面积（AUC）的影响大小进行汇总。结果荟萃分析纳入了18篇与血清Hcy和DN相关的出版物。I2检验表明，在18项研究中，诊断效果大小存在显著的统计学异质性。在随机效应模型中，合并诊断灵敏度、特异性、+LR、-L、DOR、AUC分别为0.76（95%CI:0.74-0.78）、0.84（95%CI:0.82-0.86）、5.05（95%CI:3.52-7.24）、0.27（95%CI:0.19-0.39）、21.68（95%CI:111.15至42.14）和0.90。结论血清Hcy是一种很有前景的DN血清学标志物。

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A meta-analysis of serum Hcy in diagnosis of diabetic nephropathy

Abstract Objective This meta-analysis aims to investigate the diagnostic performance of serum homocysteine (Hcy) as a biomarker for diabetic nephropathy (DN). Methods Clinical publications relevant to serum Hcy level and DN were systematic searched in the electronic databases of; Pubmed, Cochrane Library, Embase, Web of science, CNKI and CBM. The diagnostic data from each included original study was extracted and pooled by the effect size of diagnostic sensitivity, specificity, positive likely hood ratio (+LR), negative likely hood ratio (-LR), diagnostic odds ratio (DOR) and area under the symmetric ROC curve (AUC). Results 18 publications relevant to serum Hcy and DN were included in the meta-analysis. The I2 test demonstrated significant statistical heterogeneity across the 18 studies for the effect size of diagnostic. The pooled diagnostic sensitivity, specificity, +LR, -L, DOR, AUC were 0.76 (95%CI: 0.74-0.78), 0.84 (95%CI:0.82-0.86), 5.05 (95%CI:3.52-7.24), 0.27 (95%CI:0.19-0.39), 21.68 (95% CI:11.15to 42.14) and 0.90 respectively in the random effect model. Conclusion Based on the present publications, serum Hcy is a promising serological marker for DN diagnosis.

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来源期刊

Pteridines 生物-生化与分子生物学

CiteScore

1.20

自引率

25.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.