寻求幸福:理解音乐和毒品混合的机制

Kris C. Y. Lam, N. Jadavji
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引用次数: 1

摘要

不利的是,使用MDMA的一些影响包括偏执、体温升高和大量出汗,后两者与常见的死亡原因有关(Meyer, 2013)。由于没有已知的有益医疗用途,MDMA的生产,拥有和分销在世界范围内被广泛定为犯罪(Meyer, 2013)。该药物本身以片剂或胶囊形式在街头非法生产和销售,其来源是在黄樟油和香樟油中发现的一种称为黄樟油的化合物,然后进一步异构化和氧化(de la Torre等人,2004;联合国毒品和犯罪问题办公室,2014年)。不幸的是,随着MDMA在音乐节上的使用越来越受欢迎,由于需求的增加,这种药物的生产变得越来越危险,迫使制造商将他们的药物与可卡因或阿片类药物等其他物质混在一起。其他物质的添加使消费对使用者的危害更大,并增加了这些额外物质造成的过量和死亡的风险(Palamar et al., 2016)。尽管与MDMA消费相关的过量用药在全球范围内受到了媒体的广泛关注,但每年消费该药物的个人数量稳步增加,希望在参加音乐节时体验“美好时光”(Friedman et al., 2016)。众所周知,音乐听觉刺激和MDMA等精神活性兴奋剂可以促进感知者的幸福感(Bedi, Phan, Angstadt, & de Wit, 2009;Menon & Levitin, 2005)。了解MDMA和音乐刺激如何起作用的机制,以及它们在哪里相互作用,可以更好地理解将两者结合起来的激励因素,并可能找到防止在音乐节上服用MDMA导致致命过量的解决方案。这篇综述论文将整合音乐和MDMA对个人幸福的影响,分别,作为一个整体。如今的音乐节每年都吸引着成千上万的人,他们的视觉灯光,烟火表演,心跳的声音,以及与其他参与者的积极友好。然而,这些节日越来越受欢迎,也增加了一些常见的节日行为的受欢迎程度,比如饮酒和吸毒。3,4-亚甲基二氧基甲基苯丙胺,通常被称为MDMA,摇头丸,M或莫莉,已经慢慢成为节日观众的流行药物选择(Palamar, Acosta, Sherman, Ompad, & Cleland, 2016)。MDMA是一种娱乐性药物,通过刺激5-羟色胺(5-HT)、去甲肾上腺素(NE)和多巴胺(DA)的大量释放和缓慢再吸收,影响大脑,诱导情绪和感知的变化。MDMA严重激活大脑内的奖励和情感系统,从而使使用者感觉与周围的人有更多的联系,并提高他们对外部世界的感觉(Meyer, 2013)。将MDMA的精神活性作用与音乐节的感官刺激气氛相结合,使用这种药物的个体在体验这些活动中呈现给他们的视觉、听觉和触觉刺激时,报告了高度的幸福和欣快感(Van Havere et al., 2011)。寻求幸福:理解音乐和毒品混合的机制
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Seeking Happiness: Understanding the Mechanisms of Mixing Music and Drugs
Adversely, some effects of MDMA usage include paranoia, an increase in body temperature, and profuse sweating, with the latter two associated with common causes of death (Meyer, 2013). With no known beneficial medical uses, the production, possession, and distribution of MDMA is widely criminalized worldwide (Meyer, 2013). The drug itself is produced and distributed illegally at the street level in tablet or capsule form, derived from a compound found in sassafras oil and ocotea cymbarum oil called safrole which is then further isomerized and oxidized (de la Torre et al., 2004; United Nations Office on Drugs and Crime, 2014). Unfortunately, with the rising popularity of MDMA use at music festivals, the production of the drug has become increasingly dangerous due to higher demand, forcing manufacturers to lace their drugs with other substances, such as cocaine or opioids. The lacing of other substances makes consumption more harmful for the users and increases the risk of overdose and death caused by these extra substances (Palamar et al., 2016). Although overdosing linked to MDMA consumption has received widespread media attention across the world, there is a steady increase in number of individuals who consume the drug each year in hopes of experiencing a “good time” while attending a music festival (Friedman et al., 2016). Musical auditory stimuli and psychoactive stimulants like MDMA are known to promote happiness in the perceiver (Bedi, Phan, Angstadt, & de Wit, 2009; Menon & Levitin, 2005). Understanding the mechanisms of how MDMA and musical stimuli work and to where they may interact could lead to a better understanding of the motivating factors of combining the two and could potentially lead to solutions in preventing fatal overdosing caused by the consumption of MDMA at music festivals. This review paper will integrate what is known about the effects of music and MDMA on an individual’s happiness, respectively, and as a whole. INTRODUCTION Music festivals of today attract hundreds of thousands of people every year with their visual lights, pyrotechnic shows, heart-pumping sounds, and positive friendliness with other attendees. However, increased popularity of these festivals also increases popularity of common festival behaviour like the consumption of alcohol and drugs. 3,4-methylenedioxymethamphetamine, commonly referred to as MDMA, ecstasy, M, or Molly, has slowly become the popular drug of choice amongst festival-goers (Palamar, Acosta, Sherman, Ompad, & Cleland, 2016). MDMA is a recreational drug that affects the brain to induce changes in mood and perception by stimulating a larger release and slower reuptake of serotonin (5-HT), norepinephrine (NE), and dopamine (DA). MDMA heavily activates systems of reward and emotion within the brain, thus allowing users to feel more connected with those around them and heightening their senses to the external world (Meyer, 2013). Combining the psychoactive effects of MDMA with the sensory-stimulating atmospheres of music festivals, individuals using the drug report high levels of happiness and euphoria while experiencing the visual, audio, and tactile stimuli presented to them at such events (Van Havere et al., 2011). Seeking Happiness: Understanding the Mechanisms of Mixing Music and Drugs
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