钯催化2-苯并[b]噻吩或2-苯并[b]呋喃铝与杂芳基或炔基溴交叉偶联合成2-己芳基或炔基苯并[b]噻吩或苯并[b]呋喃衍生物

IF 0.7 4区化学 Q4 CHEMISTRY, ORGANIC

Letters in Organic Chemistry Pub Date : 2023-08-21 DOI:10.2174/1570178620666230821142342

Qinghan Li, Meng Liang, Jiaxia Pu, X. Jia, Lirong Han

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引用次数: 0

摘要

通过钯催化2-苯并[b]噻吩或呋喃铝分别与杂芳基溴化物或炔基溴化物交叉偶联，成功地合成了2-杂芳基或炔基苯并[b]噻吩或呋喃衍生物。这种情况是值得注意的，因为相同的催化体系可以同时产生2-取代苯并[b]噻吩或呋喃衍生物。

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Palladium-catalyzed Cross-coupling of 2-Benzo[b]thiophene or 2-Benzo[b]furan Aluminum with Heteroaryl or Alkynyl Bromides for the Synthesis of 2-Hetroaryl or Alkynyl Benzo[b]thiophene or Benzo[b]furan Derivatives

An alternative method for the synthesis of 2-heteroaryl or alkynyl benzo[b]thiophene or furan derivatives via direct palladium-catalyzed cross-coupling of 2-benzo[b]thiophene or furan aluminum with heteroaryl or alkynyl bromides, respectively, has been successfully developed. This case is remarkable as the same catalytic system could simultaneously produce either 2-substituted benzo[b]thiophene or furan derivatives.

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来源期刊

Letters in Organic Chemistry 化学-有机化学

CiteScore

1.30

自引率

12.50%

发文量

135

审稿时长

7 months

期刊介绍： Aims & Scope Letters in Organic Chemistry publishes original letters (short articles), research articles, mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts. The journal is an essential reading for all organic chemists belonging to both academia and industry.