Netarsudil-associated reticular epithelial corneal edema after phacoemulsification

Introduction: To the authors' knowledge, this is the first reported case of netarsudil-associated reticular corneal edema noted shortly after phacoemulsification with intraocular lens (IOL) implantation. Patient and Clinical Findings: A 68-year-old woman with a history of chronic angle-closure glaucoma with a long-term history of tolerance to netarsudil presented with “honeycomb” epitheliopathy shortly after phacoemulsification with IOL implantation. Diagnosis, Intervention, and Outcomes: Netarsudil was discontinued, and the patient's reticular corneal edema resolved shortly thereafter. Conclusions: Reticular corneal epitheliopathy can be seen in patients being treated with netarsudil after phacoemulsification with IOL implantation. Fortunately, this condition resolves shortly after the drug is discontinued.