2013 - 2017年北京市通州区不同剂量水痘疫苗免疫史突破水痘病例特征

Q4 Immunology and Microbiology

中华微生物学和免疫学杂志 Pub Date : 2020-02-29 DOI:10.3760/CMA.J.CN112309-20191025-00347

Chunyan Zhao, Guofeng Zhang, Ling Zhang, Jianming Zhang

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Descriptive epidemiological method was used for statistical analysis. \n \n \nResults \nFrom 2013 to 2017, Tongzhou District reported 2 102 cases of varicella in primary and middle schools and kindergartens, which included 989 cases of primary varicella, 966 breakthrough varicella cases with one-dose vaccine immunization history, and 147 breakthrough varicella cases with two-dose vaccine immunization history. There were significant differences in gender, age, and occupation among the three groups. Among the primary cases, the incidence of fever and moderate and severe rash was 46.71% and 34.68%; among the breakthrough cases with one-dose immunization history, the incidence of fever and moderate and severe rash was 41.20% and 17.39%; among the breakthrough cases with two-dose immunization history, the incidence of fever and moderate and severe rash was 26.53% and 7.48%. There were significant differences in the incidence of fever and rash among the three groups. 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引用次数: 0

摘要

目的分析2013-2017年北京市通州区不同剂量水痘疫苗接种史突破性水痘病例的流行病学特征。方法通过现场调查，查阅中国疾病预防控制中心和北京市免疫规划信息系统，获得水痘发病率和免疫史资料。采用描述性流行病学方法进行统计分析。结果2013年至2017年，通州区共报告中小学幼儿园水痘2102例，其中原发性水痘989例，有一剂疫苗免疫史的突破性水痘966例，两剂疫苗免疫历史的突破性静脉曲张147例。三组患者在性别、年龄和职业方面存在显著差异。在原发病例中，发热和中重度皮疹的发生率分别为46.71%和34.68%；在有一剂免疫史的突破性病例中，发热和中重度皮疹的发生率分别为41.20%和17.39%；在有两剂免疫史的突破性病例中，发热和中重度皮疹发生率分别为26.53%和7.48%，三组发热和皮疹发生率差异有统计学意义。水痘发病间隔的中位数在一剂免疫史组为5.11年，在两剂疫苗史组为2.44年，两者之间的差异具有统计学意义。结论水痘突破性病例的发热和皮疹症状随着疫苗接种剂量的增加而不那么非典型。由于临床症状相对较轻，作为集体感染源的突破性病例更容易被忽视。关键词：水痘；突破性案例；特点

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Characteristics of breakthrough varicella cases with different doses of varicella vaccine immunization history in Tongzhou District of Beijing during 2013 to 2017

Objective To analyze the epidemiological characteristics of breakthrough varicella cases with different doses of varicella vaccine immunization history in Beijing Tongzhou from 2013 to 2017. Methods Data about varicella incidence and immunization history were obtained through spot investigation and consulting the information systems of Chinese Disease Control and Prevention and Beijing′s Immunization Programme. Descriptive epidemiological method was used for statistical analysis. Results From 2013 to 2017, Tongzhou District reported 2 102 cases of varicella in primary and middle schools and kindergartens, which included 989 cases of primary varicella, 966 breakthrough varicella cases with one-dose vaccine immunization history, and 147 breakthrough varicella cases with two-dose vaccine immunization history. There were significant differences in gender, age, and occupation among the three groups. Among the primary cases, the incidence of fever and moderate and severe rash was 46.71% and 34.68%; among the breakthrough cases with one-dose immunization history, the incidence of fever and moderate and severe rash was 41.20% and 17.39%; among the breakthrough cases with two-dose immunization history, the incidence of fever and moderate and severe rash was 26.53% and 7.48%. There were significant differences in the incidence of fever and rash among the three groups. The median number of varicella morbidity interval was 5.11 years in one-dose immunization history group and 2.44 years in two-dose immunization history group, and the difference between them was statistically significant. Conclusions The symptoms of fever and rash in breakthrough varicella cases become less atypical as the dose of vaccination increases. Because the clinical symptoms are relatively mild, breakthrough cases as a source of infection in collective units are more likely to be neglected. Key words: Varicella; Breakthrough case; Characteristics

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来源期刊

中华微生物学和免疫学杂志 Immunology and Microbiology-Virology

CiteScore

0.50

自引率

0.00%

发文量

6906

期刊介绍： Chinese Journal of Microbiology and Immunology established in 1981. It is one of the series of journal sponsored by Chinese Medical Association. The aim of this journal is to spread and exchange the scientific achievements and practical experience in order to promote the development of medical microbiology and immunology. Its main contents comprise academic thesis, brief reports, reviews, summaries, news of meetings, book reviews and trends of home and abroad in this field. The distinguishing feature of the journal is to give the priority to the reports on the research of basic theory, and take account of the reports on clinical and practical skills.