Perbaikan kadar trigliserida dan Hs-CRP pada tikus Wistar Diabetes Mellitus tipe 2 dengan biskuit biji bunga matahari

Diabetes Mellitus is a group of metabolic diseases characterized by hyperglycemia due to defects in insulin secretion or insulin action. Increased glucose allows free fatty acids to enter as raw material for forming triglycerides. Hs-CRP can be used to identify the most sensitive inflammatory markers in diabetes. This study aims to analyze the effect of sunflower seed biscuits on triglyceride levels and Hs-CRP in Wistar rats with type 2 diabetes mellitus. The method is a true experiment with a randomized pre-post test with a control group design. The research sample size was 24 male Wistar rats, divided into four control groups K(-), K(+), and treatment P1, P2. The intervention was carried out for 28 days, and triglycerides were measured by spectrophotometer, and Hs-CRP was measured using the ELISA method. Statistical analysis used three tests, namely the Paired T-Test, the Kruskal Wallis test, and the Spearman correlation test. There are differences after the intervention and changes between groups with triglyceride values before intervention 145 mg/dl and after intervention 145 mg/dl and Hs-CRP values before intervention 14.8 mg/l and after intervention 14,8 mg/l. Changes between groups of triglyceride and Hs-CRP levels after statistical tests (p= 0,000) and (p= 0,000), respectively. The conclusion is a provision of sunflower seed biscuits showed an effect on triglyceride and Hs-CRP levels of type 2 diabetes mellitus rats. The lowest decrease in triglyceride and Hs-CRP levels was found in the treated rats with a dose of 1440 mg / 200 g of rats