三级医院扁平苔藓患者的脂质分布:一项描述性横断面研究

S. Karki, A. Rai, M. Pradhan
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引用次数: 0

摘要

背景:扁平苔藓是一种免疫介导的疾病,影响皮肤和粘膜。尽管病因和发病机制尚不完全清楚,但人们认为扁平苔藓是一种T细胞介导的炎症性疾病,会引起脂质代谢紊乱。材料和方法:临床诊断为扁平苔藓的患者在取得知情书面同意后纳入研究。共有40名患者被纳入研究。在诺贝尔医学院教学医院的医学实验室进行了血脂测定。结果:40例患者中有13例(32.5%)出现血脂异常。总体而言,女性患者(53.8%)的血脂异常发生率高于男性患者(46.2%)。在我们的研究中,最常见的变体是肥厚型(32.5%),其次是发疹型(27%)和粘膜型(25%)扁平苔藓。结论:这项研究表明,大约三分之一的扁平苔藓患者血液中的脂质水平紊乱,因此对于出现扁平苔藓的患者,医生应该考虑对他们进行血脂异常筛查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lipid Profile in Patients with Lichen Planus in a Tertiary Care Hospital: A Descriptive Cross-Sectional Study
Background: Lichen planus is an immune mediated disease that affects the skin and the mucous membranes. Although the etiology and pathogenesis are not fully understood, it is believed that lichen planus represents a T-cell-mediated inflammatory disorder which produces disturbances of lipid metabolism. Materials and Methods: Patients with the clinical diagnosis of lichen planus were included in the study after taking informed written consent. In total 40 patients were included in the study. Serum lipid profile was performed in the medical laboratory of Nobel Medical College Teaching Hospital.  Results: Out of 40 patients, 13(32.5%) patients had dyslipidemia. Overall dyslipidemia was seen more in female patients (53.8%) than in male patients (46.2%). In our study, hypertrophic (32.5%) followed by eruptive (27%) and mucosal (25%) lichen planus were the most common variant. Conclusion: This study demonstrated that about one-third of lichen planus patients showed deranged lipid levels in blood so for patients presenting with lichen planus physicians should consider screening them for dyslipidemia.
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