晚期糖基化终产物限制对糖尿病肾病患者肾功能的影响一项随机双盲临床试验

IF 0.2 Q4 UROLOGY & NEPHROLOGY

Journal of Renal Injury Prevention Pub Date : 2021-09-13 DOI:10.34172/jrip.2022.26822

Arash Dashtabi, Z. Mazloom, S. Ezzatzadegan Jahromi, M. Fararouei

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引用次数: 0

摘要

已经提出晚期糖基化终产物(AGEs)是糖尿病肾病(DN)发病的促进因素。限制饮食AGEs (dAGEs)摄入的干预措施表明临床结果有所改善。目的:本研究旨在比较基于推荐糖尿病饮食(DD)的10周低AGEs饮食(LAGEsd)与单独DD对DN患者血糖状态、血脂、血清肌酐(sCr)、血尿素氮(BUN)、尿白蛋白/肌酐比、eGFR和尿白蛋白的影响。患者和方法:对62例DN患者进行随机、双盲临床试验。将患者随机分为LAGEsd组(n=31)和DD组(n=31)，疗程10周。所有患者均按照美国糖尿病协会的建议进行卡路里调整饮食。此外，LAGEsd组的患者被指导如何根据既定的指南减少dAGEs的摄入量。收集人口统计学数据，并在干预10周前后测量饮食摄入量、体力活动水平、空腹血糖(FBS)、血红蛋白A1C (HbA1c)、血脂、sCr、血尿素氮(BUN)、估计肾小球滤过率(eGFR)、尿白蛋白/肌酐比(Alb/Cr)和尿白蛋白，并进行比较。结果:与DD组相比，LAGEsd组的日粮摄取量显著降低(P0.05)。结论:总之，限制dAGEs加DD在改善DD患者肾功能指标方面优于单独使用DD。试验注册:本研究已在伊朗临床试验注册中心注册(标识符:IRCT20191004044979N1, https://en.irct.ir/trial/42914，伦理代码:IR.SUMS.REC.1398.798)。

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Effects of dietary advanced glycation end-products restriction on renal function in patients with diabetic nephropathy; a randomized, double-blind clinical trial

Introduction: It has been proposed that advanced glycation end-products (AGEs) are contributory factors in diabetic nephropathy (DN) pathogenesis. Interventions regarding restriction dietary AGEs (dAGEs) intake indicate improvement in clinical outcomes. Objectives: The present study aimed to compare the effects of 10-week low AGEs diet (LAGEsd) based on recommended diabetic diet (DD) versus DD alone on glycemic status, lipid profile, serum creatinine (sCr), blood urea nitrogen (BUN), urine albumin to creatinine ratio, eGFR and urine albumin in patients with DN. Patients and Methods: This randomized, double-blind clinical trial was conducted on 62 patients with DN. Patients were assigned randomly to LAGEsd (n=31) and DD (n=31) groups for 10 weeks. All patients were prescribed calorie adjusted diet in regards to American Diabetes Association’s recommendation. In addition, patients in the LAGEsd group were instructed how to reduce dAGEs intake based on established guidelines. Demographic data were collected and dietary intakes, physical activity level, fasting blood sugar (FBS), hemoglobin A1C (HbA1c), lipid profile, sCr, blood urea nitrogen (BUN), estimated glomerular filtration rate (eGFR), urine albumin to creatinine ratio (Alb/Cr), and urine albumin were measured before and after of 10-weeks intervention, and compared between the two groups. Results: The results showed that dAGEs intake decreased significantly in the LAGEsd group compared with the DD group (P<0.001). In the LAGEsd group, eGFR improved significantly compared with the DD group (18.77±20.99 mL/min/1.73 m2 versus 1.57±21.06 mL/min/1.73 m2 , P=0.002); however there were no significant difference in FBS, HbA1c, lipid profile, sCr, BUN, urine Alb/Cr, and urine albumin between the two groups (P>0.05). Conclusion: In sum, dAGEs restriction plus DD is superior to DD alone in improvement of renal function marker in patients with DD. Trial Registration: This study was registered at Iranian Registry of Clinical Trials (identifier: IRCT20191004044979N1, https://en.irct.ir/trial/42914, ethical code #IR.SUMS.REC.1398.798).

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来源期刊

Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.