应用两种不同的分光光度法测定一种新的抗高血压药物组合:数据的图形和统计表示

Ragaa Magdy, A. Hemdan, N. Fares, M. Farouk
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引用次数: 0

摘要

建立了同时测定盐酸奈比洛尔和缬沙坦二元降压合剂零阶光谱的专门、精确的分光光度法。测定该降压合剂的方法有恒中心分光光度法、恒中心光谱减法分辨法和先进浓度值法。盐酸奈比洛尔在280和213 nm处用零阶光谱测定,缬沙坦在250 nm处用零阶光谱测定。将所建立的方法应用于制剂中被引药物的测定,并将测定结果与文献方法进行统计比较。结果表明,本文提出的方法与文献报道的方法在准确度和精密度方面均无显著差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Application of two different spectrophotometric approaches for the determination of a new antihypertensive combination: Graphical and statistical representation of the data
Specific, and precise spectrophotometric methods are developed and validated for the simultaneous determination of the binary antihypertensive mixture nebivolol hydrochloride and valsartan in the zero-order spectrum. The methods applied for the determination of this antihypertensive mixture are constant center spectrophotometric resolution technique, constant center spectrum subtraction resolution technique, and advanced concentration value. Nebivolol hydrochloride was determined by its zero order spectra at 280 and 213 nm while for valsartan it determined by its zero order spectra at 250 nm. All developed methods were applied for the determination of the cited drugs in the pharmaceutical formulation and the results obtained were statistically compared with each other and with those of the reported method. The comparison showed that there is no significant difference between the proposed methods and the reported method regarding both accuracy and precision.
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