Croton tiglium种子中的Tigliane型二萜类化合物

IF 1.5 4区生物学 Q3 CHEMISTRY, APPLIED

Records of Natural Products Pub Date : 2022-07-29 DOI:10.25135/rnp.344.2205.2455

Qian-Wen Niu, Lijuan Zhang, Fei-Fei Li, Jianyong Zhu

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引用次数: 0

摘要

：从巴豆种子中分离到一种新的虎杖烷型二萜（1）和三种已知的类似物（2−4）。广泛的光谱分析，特别是2D NMR实验被用来确定它们的结构。1的绝对构型由单晶X射线衍射数据定义。评价了化合物1−4对黑色素瘤细胞系A375的细胞毒性，结果表明，化合物1、3和4表现出一定的细胞毒性。

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Tigliane-Type Diterpenoids from the Seeds of Croton tiglium

: A new tigliane-type diterpenoid ( 1 ) and three known analogues ( 2 − 4 ) were isolated from the seeds of Croton tiglium . Extensive spectroscopic analyses, especially the 2D NMR experiments were used to determine their structures. The absolute configuration of 1 was defined by single-crystal X-ray diffraction data. The cytotoxicity 1 − 4 was evaluated against melanoma cell line A375, and the results showed that compounds 1 , 3 , and 4 exhibited certain cytotoxicities.

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来源期刊

Records of Natural Products 生物-医药化学

CiteScore

3.10

自引率

26.30%

发文量

审稿时长

4 months

期刊介绍： Records of Natural Products is a journal of natural product chemistry. Reviews, book reviews, research papers and short reports are considered on the substances of plants, microbes and animals. Discussions on the structure elucidation, synthesis of naturally occurring compounds and biological activity of natural compounds and plant extracts, biosynthesis of natural products and essential oils of aromatic plants as well as chemotaxonomy in the field of plants are welcomed in the journal. All published research articles in Records of Natural Products have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by expert referees.