南非林波波省mankeng医院新生儿病房新生儿持续性肺动脉高压的患病率和结局

IF 0.2 Q4 PEDIATRICS
M. Nchabeleng, Kenny Hamese, S. Ntuli
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引用次数: 0

摘要

背景。新生儿持续性肺动脉高压(PPHN)是一种高肺动脉压导致低氧血症和血液在胎儿通道上持续分流的疾病,这是出生时循环过渡失败的结果。目标。目的:确定南非林波波省mankeng医院PPHN的患病率和预后。方法。对2015年1月至2017年12月的患者档案进行回顾性描述性回顾。超声心动图诊断为PPHN。结果。在3年的研究期间,共有6776名新生儿入住新生儿病房,其中0.76% (n =52)被诊断为PPHN。其中,98% (n=51)的医疗记录中有完整的信息,并进一步分析。略多于一半(53%)为男性,59%为剖宫产,94%胎龄≥37周,39%和14%分别在1分钟和5分钟时Apgar评分<6。大多数新生儿(72%)将粪吸作为单一危险因素或与其他情况合并。近一半(45.1%)的PPHN患儿未能存活。性别、分娩方式、Apgar评分均与PPHN死亡率相关,但均无统计学意义。非幸存者接受肌力支持的比例明显高于幸存者(p <0.05)。结论。发现PPHN的患病率低于其他低收入和中等收入国家;然而,全因死亡率非常高。PPHN最常见的病因是胎粪吸入综合征,作为一个潜在的危险因素,并与其他条件相结合。大多数需要肌力支持的新生儿死亡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence and outcomes of persistent pulmonary hypertension of the newborn in a neonatal unit, Mankweng Hospital, Limpopo Province, South Africa
Background. Persistent pulmonary hypertension of the newborn (PPHN) is a condition of high pulmonary arterial pressures leading to hypoxaemia and continued shunting of blood across fetal channels as a result of failure of circulatory transition at birth. Objective. To determine the prevalence and outcomes of PPHN at Mankweng Hospital, Limpopo Province, South Africa. Methods. A retrospective descriptive review of patients’ files from January 2015 to December 2017 was conducted. PPHN was diagnosed on echocardiogram. Results. During the 3-year period of the study, a total of 6 776 neonates were admitted to the neonatal unit, of whom 0.76% ( n =52) were diagnosed with PPHN. Of these, 98% (n=51) had complete information in their medical records and were further analysed. Slightly more than half (53%) were males, 59% were delivered by caesarean section, 94% had gestational age ≥37 weeks, and 39% and 14% had Apgar scores of <6 at 1 minute and 5 minutes, respectively. Most neonates (72%) had meconium aspiration as the single risk factor or in combination with other conditions. Nearly half (45.1%) of the neonates with PPHN did not survive. Gender, mode of delivery, and Apgar score were each correlated with PPHN mortality and they all showed no statistically significant association. A significantly higher proportion of non-survivors received inotropic support than survivors ( p <0.05). Conclusions. The prevalence of PPHN was found to be lower than in other low- and middle-income countries; nonetheless, the all-cause mortality rate is significantly high. The commonest aetiology of PPHN is meconium aspiration syndrome as a single underlying risk factor, and in combination with other conditions. Most neonates who needed inotropic support died.
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来源期刊
CiteScore
0.60
自引率
0.00%
发文量
21
审稿时长
12 weeks
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