美洲鼠中草药的镇静作用及标准化参数

European Pharmaceutical Journal Pub Date : 2021-01-01 DOI:10.2478/afpuc-2020-0015

M. Shanaida, O. Golembiovska, I. Jasicka-Misiak, O. Oleshchuk, N. Beley, I. Kernychna, P. Wieczorek

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引用次数: 3

摘要

摘要由于合成镇静剂和镇静剂的各种副作用，镇静植物药物在治疗大量焦虑症状方面继续发挥着重要作用。然而，开发新的草药需要根据相关要求对其进行适当的质量控制。本研究的目的是确定从美国罗勒（Ocimum americanum L.，Lamiaceae Martinov家族）草药中获得的酊剂的镇静特性，并制定有前景的草药产品的标准化参数。采用野外试验评价了制备的酊剂的镇静效果：（1）添加美洲O.americanum精油（OATE）和（2）不添加美洲O.americanum精油。OATE的标准化参数是使用经验证的高效薄层色谱法（HPTLC）和高效液相色谱法（HPLC）制定的。HPTLC分析用于OATE中多酚的色谱指纹图谱和芳樟醇的鉴定。HPLC分析发现，OATE中迷迭香酸（RA）含量显著（0.26%）。总之，所开发的OATE可以被认为是一种具有显著镇静特性的新型中草药产品。

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Sedative Effect and Standardization Parameters of Herbal Medicinal Product Obtained from the Ocimum americanum L. Herb

Abstract Sedative phytomedications continue to play an important role in the management of a considerable amount of anxiety symptoms because of the various side effects of synthetic sedatives and tranquilizers. However, developing new herbal drugs needs their appropriate quality control according to the relevant requirements. The aim of the study was to determine the sedative properties of the tinctures obtained from the American basil (Ocimum americanum L., Lamiaceae Martinov family) herb and to develop the standardization parameters for the promising herbal medicinal product. The open field test was used to evaluate the sedative effect of the prepared tinctures: (1) with the added of O. americanum essential oil (OATEs) and (2) without adding O. americanum essential oil (OAT). The standardization parameters for the OATEs were developed using validated High-Performance Thin Layer Chromatography (HPTLC) and High-Performance Liquid Chromatography (HPLC) methods. The HPTLC analysis was used for the chromatographic fingerprints of polyphenols and for identifying linalool in the OATEs. The HPLC analysis found the significant content of rosmarinic acid (RA) (0.26%) in the OATEs. In conclusion, the developed OATEs can be considered as the new herbal medicinal product with significant sedative properties.

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来源期刊

European Pharmaceutical Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： European Pharmaceutical Journal publishes only original articles not previously published and articles that are not being considered or have not been submitted for publication elsewhere. If parts of the results have been published as conference abstract or elsewhere, it should be stated in references. The ethical standards of the Helsinki-Tokio Declaration should be kept. This should be mentioned in the Methods of manuscript. Reviews are published only on request. Authors, whose submitted research work was performed with the support of a company, should indicate this in Conflict of Interest.