局限性系统性硬化症患者口腔表现管理的挑战

Y. Lefaan, Riani Setiadhi
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引用次数: 0

摘要

背景:局限性系统性硬化症(SSc),或称硬皮病,以广泛的血管病变、过度的多器官纤维化和自身抗体为特征。SSc的早期诊断具有挑战性,因为它们与其他自身免疫性疾病相似。SSc治疗不当会增加残疾、发病率和死亡率的风险。不同的发病途径在皮肤和口腔中引起不同的表现。在这种情况下,牙医在管理口腔SSc表现方面发挥着重要作用。适当的口腔检查、诊断和治疗有助于提高患者的信心和生活质量。病例报告:一名24岁的SSc女性患者因嘴唇酸痛2周,导致进食和开口困难,从内科转诊至口腔科。做了完整的记忆和临床检查。患者被诊断为SSc引起的口腔溃疡、剥脱性唇炎、药物诱导的色素沉着、口干症和急性假膜性念珠菌感染。该患者的口腔病变被认为是由SSc引起的口腔溃疡,因为患者在溃疡出现之前已经停止使用甲氨蝶呤2周。口服治疗包括氯化钠(NaCl 0.9%)、凡士林相册、透明质酸漱口水和制霉菌素。治疗3天后,口腔病变有明显改善。结论:患者口腔SSc表现为微小切口、舌僵和口腔溃疡,导致临床检查和诊断不充分。这种口服SSc的治疗具有挑战性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Challenges in the management of oral manifestations in a patient with limited systemic sclerosis
Background: Limited systemic sclerosis (SSc), or scleroderma, is characterized by widespread vasculopathy, excessive multiorgan fibrosis, and autoantibody. The early stages of SSc are challenging to diagnose because of their similarity to other autoimmune conditions. Inappropriate SSc treatment can increase the risk of disability, morbidity, and mortality. Different pathogenesis pathways incur various manifestations in the skin and the oral cavity. In this scenario, dentists play an essential role in managing oral SSc manifestations. Proper oral examination, diagnosis, and therapy help to increase the confidence and patient’s quality of life. Case Report: A 24-year-old female patient with SSc was referred from the Internal Medicine Department to the Oral Medicine Department because of lip soreness for 2 weeks, resulting in difficulty eating and opening the mouth. A complete anamnesis and clinical examination were done. The patient was diagnosed with an oral ulcer caused by SSc, cheilitis exfoliative, drug-induced pigmentation, xerostomia, and acute pseudomembranous candidiasis. The oral lesion in this patient was concluded as an oral ulcer caused by SSc because the patient had already stopped using methotrexate for 2 weeks before the ulceration appeared. The oral treatment included sodium chloride (NaCl 0.9%), vaseline album, hyaluronic acid mouthwash, and nystatin. Oral lesions had a significant improvement after 3 days of treatment. Conclusion: The SSc manifestation that appeared on the oral cavity of the patient as microstomia, tongue stiffness, and oral ulcer resulted in inadequate clinical examination, and diagnosis. Treatments for this oral SSc were challenging.
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