利用牛膝提取物生物合成银纳米颗粒发现对临床分离的耐多药细菌以及MCF-7和AGS细胞系的高抗菌和抗肿瘤作用

M. Ebrahimzadeh, S. R. Alizadeh, Z. Hashemi
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引用次数: 0

摘要

绿色技术是生产功能性纳米颗粒的一种独特方式。我们研究了牛膝提取物绿色合成Ag纳米颗粒(O-AgNPs)的方法。通过监测浓度、pH、反应时间和温度等关键因素,实现了绿色合成的O-AgNPs。几种分析技术,包括扫描电子显微镜、能量色散X射线光谱、X射线衍射分析和UV-Vis光谱,被用于表征O-AgNPs。SEM分析显示O-AgNPs具有球形形状和33.57nm的平均尺寸。XRD图谱表明所制备的O-AgNPs具有面心立方(fcc)结构。在MCF-7(乳腺)和AGS(胃)细胞系中研究了合成的O-AgNPs的抗癌活性,表明其对所选细胞系具有很高的抗癌作用。O-AgNPs抑制了所有选择的含有Gram+和Gram-的细菌的生长。与传统抗生素相比,O-AgNPs表现出更大的抑制作用。因此,我们使用植物提取物绿色合成的AgNPs表现出抗癌和抗菌活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Discovery of high antibacterial and antitumor effects against multi-drug resistant clinically isolated bacteria and MCF-7 and AGS cell lines by biosynthesized silver nanoparticles using Oxalis corniculata extract
The green technique is a unique way to produce functional nanoparticles. We examined the green synthesis of Ag nanoparticles (O-AgNPs) by the extract of Oxalis corniculata. Green-synthesized O-AgNPs were accomplished by monitoring critical factors such as concentration, pH, reaction time, and temperature. Several analytical techniques, including scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction analysis, and UV-Vis spectroscopy, were applied to characterize O-AgNPs. The SEM analysis showed O-AgNPs with a spherical shape and an average size of 33.57 nm. The XRD pattern indicated the face-centered cubic (fcc) structure of the prepared O-AgNPs. The anticancer activity of the synthesized O-AgNPs was investigated in MCF-7 (breast) and AGS (gastric) cell lines, indicating high anticancer effects against selected cell lines. The growth of all selected bacteria containing Gram+ and Gram- was inhibited by O-AgNPs. O-AgNPs showed greater inhibition in comparison to conventional antibiotics. As a result, our green synthesized AgNPs using plant extracts exhibited anticancer and antibacterial activities.
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