Scientific and Pharmaceutical Aspects of Christensenella minuta, a Promising Next-Generation Probiotic

Christensenella minuta (C. minuta), a member of a recently described bacterial family, is one of the most heritable next-generation probiotics. Many observational studies confirmed that the relative abundance of C. minuta is associated with lean body types with a low host body mass index (BMI), and is also influenced by age, diet, and genetics. By utilizing its benefits, it could be suited to many therapies, including human and animal health as well. However, a reliable method for culturing the strain must also be developed to enable the therapeutic administration of the microbe. Sludge microfiltration could be a promising solution for large scale-up cultivation. In this review, different processing methods are also described from pharmaceutical aspects.