潜在致癌空气污染物暴露和早期损害的化学生物标志物

K. Luo, I. Stepanov, S. Hecht
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引用次数: 6

摘要

流行病学和实验室研究支持空气污染对人类致癌的结论。化学特异性生物标志物可用于确定人体暴露于空气污染中潜在有毒和致癌成分及其代谢,以及区分空气污染和烟草烟雾造成的暴露。代表性的化学特异性生物标志物,定量的质谱和相关技术进行了讨论。这些生物标志物与暴露于多环芳烃、挥发性毒物和致癌物、氧化剂、DNA损伤化合物和污染空气中发现的金属有关。可量化的化学特异性生物标志物可能在空气污染致癌研究中有用,包括尿1-羟基芘、苯并[a]芘、菲、苯、1,3-丁二烯、丙烯醛和巴丁醛的代谢物,以及氧化损伤的产物,如尿8-羟基-2'-脱氧鸟苷、丙二醛和f2 -异前列腺素、某些DNA加合物和金属。烟草特异性代谢物,如可替宁和4-(甲基亚硝胺)-1-(3-吡啶基)-1-丁醇,可用于区分与烟草有关的暴露与由空气污染引起的暴露。以下经过验证的化学特异性生物标志物是目前用于空气污染和癌症研究的最佳生物标志物:尿1-羟基芘、菲代谢产物、s -苯基巯基酸、尿或血Cd、8-羟基脱氧鸟苷和f2 -异前列腺素(如8- iso - pgf 2α)。这套生物标志物将可靠地确定致癌多环芳烃、苯和镉的暴露情况,并将提供关于氧化损伤和炎症的关键信息,这两者在致癌过程中都很重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chemical biomarkers of exposure and early damage from potentially carcinogenic airborne pollutants
Epidemiology and laboratory studies support the conclusion that air pollution is carcinogenic to humans. Chemically specific biomarkers are useful for determining human exposure to, and metabolism of, potentially toxic and carcinogenic components of air pollution, and distinguishing exposures due to air pollution from those resulting from tobacco smoke. Representative chemically specific biomarkers, quantified by mass spectrometry and related techniques, are discussed. The biomarkers are related to exposure to polycyclic aromatic hydrocarbons, volatile toxicants and carcinogens, oxidants, DNA damaging compounds, and metals found in polluted air. Quantifiable chemically specific biomarkers potentially useful in studies of air pollution carcinogenesis include urinary 1-hydroxypyrene, metabolites of benzo[ a ]pyrene, phenanthrene, benzene, 1,3-butadiene, acrolein, and crotonaldehyde, as well as products of oxidative damage such as urinary 8-hydroxy-2'-deoxyguanosine, malondialdehyde, and F 2 -isoprostanes, certain DNA adducts, and metals. Tobacco-specific metabolites such as cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol can be used to distinguish tobacco-related exposures from those resulting from air pollution. The following validated chemically specific biomarkers are currently the optimal ones for use in studies of air pollution and cancer: urinary 1-hydroxypyrene, phenanthrene metabolites, S-phenyl mercapturic acid, urinary or blood Cd, 8-hydroxydeoxyguanosine and F 2 -isoprostanes such as 8- iso -PGF 2α . This suite of biomarkers will reliably establish exposure to carcinogenic polycyclic aromatic hydrocarbons, benzene and Cd, and will also provide critical information on oxidative damage and inflammation, both of which are important in carcinogenesis.
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