β -谷甾醇，白桦酸，生物茶素A和熊果酸的遗传毒性，潜在的驱虫药植物化合物

Q4 Pharmacology, Toxicology and Pharmaceutics

Toxicology International Pub Date : 2023-05-19 DOI:10.18311/ti/2023/v30i2/30946

V. Mishra, A. Yadav, Amar Deep Soren

{"title":"β -谷甾醇，白桦酸，生物茶素A和熊果酸的遗传毒性，潜在的驱虫药植物化合物","authors":"V. Mishra, A. Yadav, Amar Deep Soren","doi":"10.18311/ti/2023/v30i2/30946","DOIUrl":null,"url":null,"abstract":"Beta-sitosterol, betulinic acid, biochanin A and ursolic acid are known to possess anthelmintic properties. This study was undertaken to assess the genotoxic potentials of these phytocompounds in albino rats. Animals were orally administered with 1 and 10 mg/ml of the above phyto-compounds for a period of 14 days. All the animals were subjected to mitotic arrest before sacrifice and then bone marrow cells were collected from both the femurs and processed to observe the chromosomal aberrations. The results revealed that ursolic acid induced the maximum number of statistically significant abnormalities (p ≤ 0.05) followed by betulinic acid and biochanin A. Beta-sitosterol was found to be the safest of all the tested phytocompounds as far as chromosomal abnormalities in short term oral studies are concerned as it did not lead to major changes at genomic level. Although these phyto-compounds are considered potential anthelmintics, their long-term use may cause genotoxic effects to the users.","PeriodicalId":23205,"journal":{"name":"Toxicology International","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Genotoxicity of Beta-Sitosterol, Betulinic Acid, Biochanin A, and Ursolic Acid, Potential Anthelmintic Phyto-Compounds\",\"authors\":\"V. Mishra, A. Yadav, Amar Deep Soren\",\"doi\":\"10.18311/ti/2023/v30i2/30946\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Beta-sitosterol, betulinic acid, biochanin A and ursolic acid are known to possess anthelmintic properties. This study was undertaken to assess the genotoxic potentials of these phytocompounds in albino rats. Animals were orally administered with 1 and 10 mg/ml of the above phyto-compounds for a period of 14 days. All the animals were subjected to mitotic arrest before sacrifice and then bone marrow cells were collected from both the femurs and processed to observe the chromosomal aberrations. The results revealed that ursolic acid induced the maximum number of statistically significant abnormalities (p ≤ 0.05) followed by betulinic acid and biochanin A. Beta-sitosterol was found to be the safest of all the tested phytocompounds as far as chromosomal abnormalities in short term oral studies are concerned as it did not lead to major changes at genomic level. Although these phyto-compounds are considered potential anthelmintics, their long-term use may cause genotoxic effects to the users.\",\"PeriodicalId\":23205,\"journal\":{\"name\":\"Toxicology International\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-05-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxicology International\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18311/ti/2023/v30i2/30946\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicology International","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18311/ti/2023/v30i2/30946","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}

引用次数: 0

摘要

已知-谷甾醇、白桦酸、生物茶素A和熊果酸具有驱虫特性。本研究旨在评估这些植物化合物对白化大鼠的遗传毒性。动物分别口服上述植物化合物1和10 mg/ml，为期14天。所有动物在献祭前进行有丝分裂阻滞，然后从股骨两侧采集骨髓细胞，观察染色体畸变。结果显示，熊果酸引起的染色体异常数量最多(p≤0.05)，其次是白桦酸和生物茶素a。在短期口服研究中，β -谷甾醇是所有被测试的植物化合物中最安全的，因为它不会导致基因组水平的重大变化。虽然这些植物化合物被认为是潜在的驱虫药，但长期使用可能对使用者造成遗传毒性作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Genotoxicity of Beta-Sitosterol, Betulinic Acid, Biochanin A, and Ursolic Acid, Potential Anthelmintic Phyto-Compounds

Beta-sitosterol, betulinic acid, biochanin A and ursolic acid are known to possess anthelmintic properties. This study was undertaken to assess the genotoxic potentials of these phytocompounds in albino rats. Animals were orally administered with 1 and 10 mg/ml of the above phyto-compounds for a period of 14 days. All the animals were subjected to mitotic arrest before sacrifice and then bone marrow cells were collected from both the femurs and processed to observe the chromosomal aberrations. The results revealed that ursolic acid induced the maximum number of statistically significant abnormalities (p ≤ 0.05) followed by betulinic acid and biochanin A. Beta-sitosterol was found to be the safest of all the tested phytocompounds as far as chromosomal abnormalities in short term oral studies are concerned as it did not lead to major changes at genomic level. Although these phyto-compounds are considered potential anthelmintics, their long-term use may cause genotoxic effects to the users.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Toxicology International Environmental Science-Health, Toxicology and Mutagenesis

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： Toxicology International is a peer-reviewed International Research Journal published bi-annually by the Society of Toxicology, India. The Journal is concerned with various disciplines of Toxicology including man, animals, plants and environment and publishes research, review and general articles besides opinions, comments, news-highlights and letters to editor.