评价噪声污染对雄性Wistar大鼠血液皮质醇、睾酮和甲状腺水平的影响

IF 0.6 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Seyed-Hosein Abtahi-Eivary, Ali Tajpoor, A. Firoozi, Shahrzad Mehrzad, M. Beheshti
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引用次数: 1

摘要

背景:噪音污染是一个全球性的问题,引起各种激素分泌的变化,从而影响城市的社会福祉和生活质量。目的:探讨噪声污染对雄性大鼠睾丸激素、甲状腺激素和皮质醇水平的影响。方法:选用雄性Wistar大鼠70只(200 ~ 250 g),随机分为1个对照组和6个实验组,每组10只。各组噪声暴露强度(dB)和时间(min)分别为:(1)60 dB, 30 min;(II) 60 dB, 60 min;(III) 85 dB, 30 min;(IV) 85 dB, 60 min;(V) 110db, 30min;(VI) 110 dB, 60 min;(七)控制。实验组的动物在为此目的而设计的声学室中暴露在噪音中50天。使用noise .exe软件产生噪声,使用声级计(型号TES 1358)确定声音强度和频率的准确性。为了测定血浆中激素的水平,使用了适当的基于ELISA法的研究和商业试剂盒。为了测定除TSH以外的激素浓度,使用了人用测定试剂盒。所有统计检验均在SPSS软件21版中进行。结果:110-dB(30、60 min)、65-dB (60 min)、85-dB (60 min)组血清皮质醇水平均显著高于对照组(P≤0.05)。此外,65-dB和85-dB(30分钟)组的皮质醇水平高于对照组;但差异不显著(P < 0.05)。60 db、85 db组患者T4、T3、TSH水平均显著低于对照组(P≤0.05)。110-dB组患者血清T4、T3、TSH水平均低于对照组(P < 0.05)。110-dB组血清睾酮水平显著低于对照组(P≤0.05)。65 db组和85 db组的平均血清睾酮水平均低于对照组(P < 0.05)。结论:基于本研究,暴露于噪声污染中会增加大鼠的皮质醇分泌,降低T4、T3、TSH和睾酮水平。由于这种激素失衡可能产生直接和间接的影响,建议研究和策略来控制污染环境中激素失衡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluating the Effects of Noise Pollution on the Levels of Blood Cortisol, Testosterone, and Thyroid in Male Wistar Rats
Background: Noise pollution is a global problem causing changes in the secretion of various hormones and consequently affecting social well-being and quality of life in cities. Objectives: This study aimed to investigate the effect of noise pollution on the levels of testosterone, thyroid, and cortisol hormones in male rats. Methods: In this experimental study, a total of 70 male Wistar rats (200 - 250 g) were randomly assigned into one control and six experimental groups, with 10 rats in each group. Experimental groups were exposed to noise with different intensity (dB) and time (min) as follows: (I) 60 dB, 30 min; (II) 60 dB, 60 min; (III) 85 dB, 30 min; (IV) 85 dB, 60 min; (V) 110 dB, 30 min; (VI) 110 dB, 60 min; (VII) controls. Animals in the experimental groups were exposed to noise in an acoustic chamber designed for this purpose for 50 days. The Noise.exe software was used to generate noise, and the sound level meter (model TES 1358) was used to determine the accuracy of the intensity and frequency of sound. To determine plasma levels of the hormones, appropriate research and commercial kits were used, which were based on the ELISA method. To determine the concentration of hormones other than TSH, human assay kits were used. All statistical tests were performed in SPSS software version 21. Results: Serum levels of cortisol in the 110-dB (30 and 60 min), 65-dB (60 min), and 85-dB (60 min) groups were significantly higher than the control group (P ≤ 0.05). Also, cortisol levels in the 65-dB and 85-dB (30 minutes) groups were higher than the control group; however, the increase was not significant (P > 0.05). The levels of T4, T3, and TSH in the 60-dB and 85-dB groups were significantly lower than in the control group (P ≤ 0.05). The serum levels of T4, T3, and TSH hormones in the 110-dB group were insignificantly lower than the control group (P > 0.05). The serum level of testosterone in the 110-dB group was significantly lower than the control group (P ≤ 0.05). The mean serum levels of testosterone in the 65-dB and 85-dB groups were insignificantly lower than the control group (P > 0.05). Conclusions: Based on this study, exposure to noise pollution increased cortisol secretion and decreased T4, T3, TSH, and testosterone levels in rats. As this hormonal imbalance may create direct and indirect effects, studies and strategies are recommended to control the imbalance of hormones in the polluted environments.
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来源期刊
Health Scope
Health Scope PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
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