褐藻Pyropia yezoensis的脂溶性部分对小鼠酒精性肝损伤的保护作用

IF 3.1 3区生物学 Q1 MARINE & FRESHWATER BIOLOGY

Algae Pub Date : 2021-09-15 DOI:10.4490/algae.2021.36.4.28

Ji-Hyeok Lee, Ginne Ahn, J. Ko, Nalae Kang, K. Jung, E. Han, G. Kim, Hee Jeong Kim, C. Choi, Y. Jeon

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引用次数: 1

摘要

本文研究了黄颡鱼脂溶性部分对小鼠酒精性肝损伤的保护作用。脂肪酸在PYLP中占主导地位，PYLP在超声处理后由70%EtOH提取物的己烷部分获得。特别是二十碳五烯酸和亚油酸等多不饱和脂肪酸占总脂质的56.91%。PYLP显著降低了酒精治疗引起的小鼠肝损伤。PYLP处理通过减少硫代巴比妥酸反应物质，提高了抗氧化酶的活性，包括超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶。组织学观察表明，PYLP通过调节参与抗凋亡信号通路的蛋白质的表达水平，最大限度地减少了酒精处理对活组织的损伤。我们的研究结果表明，PYLP富含从褐藻P.yezoensis中提取的多不饱和脂肪酸，将在宿醉行业中用作潜在的肝脏保护剂。

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Liposoluble portion of the red alga Pyropia yezoensis protects alcohol induced liver injury in mice

The hepatoprotective effect of liposoluble portion of Pyropia yezoensis (PYLP) was investigated against alcohol-induced liver injury in mice. Fatty acids were predominant in PYLP obtained from hexane fraction of 70% EtOH extract after ultrasonication. In particular, polyunsaturated fatty acids such as eicosapentaenoic acid and linoleic acid accounted for 56.91% of the total lipids. PYLP significantly reduced liver damage induced by the alcohol treatment in mice. PYLP treatment increased the activity of antioxidant enzymes including superoxide dismutase, catalase, and glutathion peroxidase by reducing thiobarbituric acid reactive substances. Histological observations showed that PYLP minimizes damage to living tissue induced by alcohol treatment by modulating the expression level of proteins involved in the anti-apoptotic signaling pathway. Our results suggest that PYLP, rich in polyunsaturated fatty acids extracted from the red alga P. yezoensis, will be useful as a potential liver protectant in the hangover industry.

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来源期刊

Algae PLANT SCIENCES-

CiteScore

5.10

自引率

25.00%

发文量

期刊介绍： ALGAE is published by the Korean Society of Phycology and provides prompt publication of original works on phycology. ALGAE publishes articles on all aspects of phylogenetics and taxonomy, ecology and population biology, physiology and biochemistry, cell and molecular biology, and biotechnology and applied phycology. Checklists or equivalent manu-scripts may be considered for publication only if they contribute original information on taxonomy (e.g., new combinations), ecology or biogeography of more than just local relevance. Contributions may take the form of Original Research Articles, Research Notes, Review Articles and Book Reviews.