New Manifestation of Covid-19 in Oral Region, a Potential Faster Diagnosis Approach, a Mini Review

Introduction: The pandemic of COVID-19 continues to shatter the world by high rate of mortalities. The poorest prognosis of COVID-19 is among patients with comorbidities. Exploring new ways to predict and diagnose the infection at early stages will probably reduce the fatality and prevent further damages. Identifying unexampled or additional clinical symptoms may provide opportunities for earlier diagnosis and prevention of severe cases of COVID-19. Material and method: A methodical search was conducted through PubMed, Google and Google scholar databases to analyze the published or in press literature. The keywords were words “novel Coronavirus”, “SARS-Cov-2 (CoV)” and “COVID-19”, searched by at least two or more independent individuals. A total of 88 related items were picked based on the keywords. While the majority of materials were based on one-case reports (66 cases), a combination of multiple case studies as well as full research papers was investigated. Results: There were several unexampled manifestations including cutaneous symptoms and oral lesions by which early diagnosis, prevention and even more effective treatment may be achieved for COVID-19 patients. Conclusion: The most striking novel clinical presentation was intraoral painful blisters or mouth ulcers mostly seen on the cheek mucosa as per the revelation of the reported cases in the literature review. Leaving out a daily intraoral examination might have been the reason why intraoral lesions have been connived as effective predictive, prognostic and even preventive manifestations of COVID-19. The outcomes of these current studies suggest that intraoral lesions may offer a very new approach, using preventive, predictive and personalized medicine (PPP) concept to provide a rapid diagnosis and more effective therapeutic modality in patients with COVID-19. Keywords: COVID-19; Oral lesions; SARS-CoV-2; PPP; Preventive; coronavirus; Personalized Abbreviations: PPP: preventive predictive and personalized medicine, SARS: Severe Acute Respiratory Syndrome, COVID: corona virus disease.