寄生虫感染给药策略综述:范围与主张

Q2 Pharmacology, Toxicology and Pharmaceutics
M. Bhatia, Sunil Kumar, A. Kapoor, Sunidhi Lohan
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引用次数: 1

摘要

寄生虫感染是全世界发病率和死亡率的主要原因。在治疗这些感染方面取得了重大进展,如抗寄生虫药物的发现、新的配方策略的制定以及定点给药和化疗等。由于合成药物是危险的,并且有各种副作用,导致耐药性的发展和健康的丧失。草药经济实惠,而且通常没有潜在的副作用,受到了广泛的认可。然而,生产抗寄生虫疫苗是困难的,已经作出了重大努力,但目前仍然没有许可的疫苗可用于控制人类寄生虫疾病。本文对寄生虫感染治疗的各种技术进行了系统的评价。此外,还研究了在开发更有效的药物输送系统方面建立新趋势所涉及的进展和挑战。在过去的一段时间里,人类中即将发生的传染性疾病的数量有所增加,或者在未来有增加的迹象。在过去的30年里,全球已经发现了30多种新的感染病原体;其中约60%来自人畜共患疾病。有效的给药在治疗寄生虫感染中起着关键作用。现代抗寄生虫药物给药系统的主要目标是尽量减少潜在的副作用,并将药物直接带到目标病原体,因此,为了改善许多人类寄生虫疾病的危急情况,需要比简单的片剂或溶液更复杂的药物配方。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A review on the drug delivery strategies for parasitic infections: scope and assertion
Parasitic infections are prime causes of morbidity and mortality worldwide. Significant progress has been made to cure these infections like discovery of antiparasitic drugs, developing new formulation strategies and site-directed drug delivery and chemotherapy etc. As synthetic drugs are perilous and have various side effects leading to the development of drug resistance and loss of health. Herbal medicines are economical and generally free from potential side effects is acclaiming recognition. However, it is difficult to produce antiparasitic vaccines, major efforts have been made and still there are no licensed vaccines currently available to control human parasitic ailments. Here, a systematic review is dispensed assessing various techniques for the treatment of parasitic infections. Moreover, the advancements and challenges involved in establishing novel trends in the development of a more effective drug delivery systems are also investigated. The numbers of impending infectious ailments in humans have enhanced within the novel past or warn to increase in the future. Over thirty new infective agents have been identified globally in the last 30 years; approximately 60 % of these are from zoonotic sources. Efficient drug delivery plays a key role in treating parasitic infections. The main goal of modern antiparasitic drug delivery system is to minimize the potential side effects and bring the drug directly to the target pathogens, therefore, more sophisticated drug formulations than a simple tablet or solution are necessary for the betterment of critical situations of many human parasitic diseases.
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来源期刊
Drug Delivery Letters
Drug Delivery Letters Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
CiteScore
1.70
自引率
0.00%
发文量
30
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