阿曲库铵预处理与硫酸镁预防磺胺硫铵诱导的束状收缩和术后肌痛的疗效比较

E. O. Folami, T. Olajumoke, I. Kolawole, A. Ojo, S. Raji, R. O. Folami
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引用次数: 0

摘要

背景:舒沙美铵仍然是快速序列诱导的最佳选择,它是临床上唯一的去极化肌肉松弛剂。然而,束发和肌痛是该药物常见的不良反应。肌痛可持续数天,并伴有不适。非去极化肌肉松弛剂和硫酸镁已被尝试作为预处理,以减轻肌束和肌痛,结果各不相同。方法:一项双盲随机研究招募了100名ASA I或II级的成年外科患者,接受静脉注射阿曲库铵(0.05mg/kg)(A组)或静脉注射硫酸镁(30mg/kg)(B组)。还记录了束发的发生、严重程度和持续时间,以及术后肌痛的发生和严重程度。结果:A组39例(78%)患者和B组27例(54%)患者出现肌肉束聚(p=0.001)。B组束聚的严重程度为轻度至中度,A组还记录了一些严重束聚的病例。A组的平均分束持续时间(28.48±1.07秒)长于B组(19.44±1.93秒)(p=0.001)。术后6小时和48小时没有出现肌痛,而2名患者(每组1名)在12小时出现肌痛。24小时时,A组13名(26%)患者和B组5名(10%)患者出现术后肌痛(p=0.043)。术后12小时和24小时记录的肌痛严重程度均为轻度。结论:硫酸镁比阿曲库铵具有更好的减少束发和术后肌痛的疗效
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of the efficacy of atracurium pretreatment versus magnesium sulphate for prevention of suxamethonium-induced fasciculation and post-operative myalgia
Background: Suxamethonium remains the best option for rapid sequence induction, it is the only depolarizing muscle relaxant in clinical use. However, fasciculation and myalgia are frequent adverse effects of the drug. Myalgia can last for several days with associated discomfort. Non-depolarizing muscle relaxant and magnesium sulphate have been tried as pretreatments to attenuate the fasciculation and myalgia with varying results.Methods: A double blind, randomized study of 100 adult surgical patients of ASA I or II Class were recruited to receive either intravenous atracurium (0.05mg/kg) (Group A) or intravenous magnesium sulphate (30mg/kg)(Group B). The occurrence, severity and duration of fasciculation as well as the occurrence and severity of post-operative myalgia were also recorded.Results: Muscle fasciculation occurred in 39 (78%) patients in Group A and 27(54%) patients in Group B (p= 0.001). The severity of fasciculation was mild to moderate in Group B while Group A in addition also recorded some cases of severe episodes of fasciculation. Mean duration of fasciculation in Group A waslonger (28.48 ± 1.07sec) than in group B (19.44± 1.93seconds) (p= 0.001). Post-operative myalgia was not experienced at 6hrs and 48hrs, while 2 patients (1 in each Group) had it at 12hrs. At 24hrs, postoperative myalgia was present in 13(26%) patients in group A and 5(10%) patients in group B, (p=0.043). The severity of post-operative myalgia recorded both at 12hrs and 24hrs was mild.Conclusion: Magnesium sulphate demonstrated better efficacy at reducing fasciculation and postoperative myalgia than atracurium
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