奥地利儿童和青少年糖尿病发病率持续上升（1989-2021）：全国登记结果

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Pediatric Diabetes Pub Date : 2023-08-18 DOI:10.1155/2023/4616903

K. Nagl, T. Waldhör, S. Hofer, Nicole Blauensteiner, M. Fritsch, E. Fröhlich-Reiterer, B. Rami-Merhar

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引用次数: 0

摘要

介绍由于在儿童和青少年时期没有统一的全球糖尿病趋势，因此对糖尿病发病率进行区域流行病学调查很重要。在奥地利，1型糖尿病（T1D）、2型糖尿病（T2D）和其他形式糖尿病的发病率已经记录了几十年。方法。分析几十年来奥地利全国范围内15岁以下儿童糖尿病前瞻性人群发病率研究中糖尿病发病率的最新进展。我们通过联合点分析估计了1989年至2021年T1D和T2D年龄标准化率的时间趋势。计算年变化百分比（APC）。案件查明率为97%。后果我们观察到2021年T1D发病率异常增加，达到28.7/10000/PY（人-年）的峰值。从2011年到2020年，总队列中存在一个恒定的平稳期（APC 0.78，95%CI[-0.99，2.58]，p=0.379），这是在1989年到2011年T1D发病率急剧增加（APC 4.6，95%CI[3.94，5.19]，p<0.001）之后发生的。观察到T1D发病发展的年龄特异性差异。在观察期内，我们首次观察到T2D持续增加，具有统计学意义（APC 3.47，95%CI[0.76，6.26]，p=0.014）。在这个年龄组中，其他形式的糖尿病的发病率是T2D的两倍。结论奥地利15岁以下儿童的T1D发病率仍在增加，并在2021年达到峰值。奥地利首次观察到儿童T2D的显著增加。

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Ongoing Increase in Incidence of Diabetes in Austrian Children and Adolescents (1989–2021): Results from a Nationwide Registry

Introduction. Since there is no uniform global diabetes trend in childhood and adolescence, regional epidemiological surveys of diabetes incidences are important. In Austria, the incidences of type 1 diabetes (T1D), type 2 diabetes (T2D), and other forms of diabetes have been recorded for decades. Methods. To analyze recent developments of diabetes incidence within the decades long-standing Austrian nationwide prospective population-based incidence study for diabetes in children aged <15 years. We estimated time trends of age-standardized rates from 1989 to 2021 for T1D and T2D by joinpoint analysis. Annual percent changes (APCs) were calculated. Case ascertainment was 97%. Results. We observed an unusual increase of T1D incidence in the year 2021, reaching a peak of 28.7/100,000/PY (person years). From 2011 to 2020, there had been a constant plateau phase in the total cohort (APC 0.78, 95% CI [−0.99, 2.58], p = 0.379 ), which had followed a steep increase of T1D incidence (APC 4.6, 95% CI [3.94, 5.19], p < 0.001 ) from 1989 to 2011. Age-specific differences in T1D incidence development were observed. For the first time, we observed a statistically significant constant increase in T2D during the observation period (APC 3.47, 95% CI [0.76, 6.26], p = 0.014 ). Other forms of diabetes are two times more common than T2D in this age group. Conclusion. The incidence of T1D in Austrian children <15 years is still increasing and showed a peak in 2021. For the first time, a significant increase in pediatric T2D was observed in Austria.

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来源期刊

Pediatric Diabetes 医学-内分泌学与代谢

CiteScore

6.60

自引率

14.70%

发文量

141

审稿时长

4-8 weeks

期刊介绍： Pediatric Diabetes is a bi-monthly journal devoted to disseminating new knowledge relating to the epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes in childhood and adolescence. The aim of the journal is to become the leading vehicle for international dissemination of research and practice relating to diabetes in youth. Papers are considered for publication based on the rigor of scientific approach, novelty, and importance for understanding mechanisms involved in the epidemiology and etiology of this disease, especially its molecular, biochemical and physiological aspects. Work relating to the clinical presentation, course, management and outcome of diabetes, including its physical and emotional sequelae, is considered. In vitro studies using animal or human tissues, whole animal and clinical studies in humans are also considered. The journal reviews full-length papers, preliminary communications with important new information, clinical reports, and reviews of major topics. Invited editorials, commentaries, and perspectives are a regular feature. The editors, based in the USA, Europe, and Australasia, maintain regular communications to assure rapid turnaround time of submitted manuscripts.