蛋白质相互作用数据的综合meta分析鉴定出植物中多个GID/MRCTLH蛋白复合物

Q3 Agricultural and Biological Sciences

Plant Omics Pub Date : 2017-04-20 DOI:10.21475/POJ.10.04.17.PNE212

M. Miquel, C. Vicient

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引用次数: 3

摘要

GID/MRCTLH是一种蛋白质复合体，通过多泛素化和蛋白体降解参与多种细胞过程的调节。它已在酵母和哺乳动物中被描述。编码同源蛋白质的基因也存在于植物基因组中，但研究很少。BLAST分析显示，与哺乳动物和酵母相比，编码GID/MRCTLH复合物成员的基因在植物中存在多个拷贝。基于拟南芥蛋白质相互作用数据库Interactome 2.0来估计拟南芥GID/MRCTLH复合物的潜在结构。根据这些数据，拟南芥可能含有两种GID/MRCTLH复合物，而不是酵母和哺乳动物中描述的复合物。这两种拟南芥复合物的结构似乎与酵母GID复合物相似，并且似乎与复合物中的其他几种蛋白质相互作用。这些数据表明，与酵母和哺乳动物类似，植物GID/MRCTLH复合物通过蛋白体蛋白降解参与多种细胞过程的调节。

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Integrative meta-analysis of protein interaction data identified multiple GID/MRCTLH protein complexes in plants

GID/MRCTLH is a protein complex involved in the regulation of several cellular processes through the polyubiquitination and proteosome degradation. It has been described in yeast and mammals. Genes coding for homologous proteins are also present in plant genomes but have been little studied. BLAST analyses revealed that genes coding for members of the GID/MRCTLH complex are found in multiple copies in plants, compared to mammals and yeast. The potential structure of the Arabidopsis GID/MRCTLH complex was estimated based on the Arabidopsis protein interaction database Interactome 2.0. According to these data, Arabidopsis may contain two GID/MRCTLH complexes instead of the one described in yeast and mammals. The structure of the two Arabidopsis complexes seem to be similar to the yeast GID complex, and seem to interact with several other proteins out of the complex. These data suggest that, similarly to yeast and mammals, the plant GID/MRCTLH complexes are involved in the regulation of several cellular processes through proteosome protein degradation.

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来源期刊

Plant Omics 生物-植物科学

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Plant OMICS is an international, peer-reviewed publication that gathers and disseminates fundamental and applied knowledge in almost all area of molecular plant and animal biology, particularly OMICS-es including: Coverage extends to the most corners of plant and animal biology, including molecular biology, genetics, functional and non-functional molecular breeding and physiology, developmental biology, and new technologies such as vaccines. This journal also covers the combination of many areas of molecular plant and animal biology. Plant Omics is also exteremely interested in molecular aspects of stress biology in plants and animals, including molecular physiology.