Promising approaches to assessing the public health risk with real ways of entering a toxicant into the body

The paper discusses promising directions of scientific and technological development of the Russian Federation in the field of ecology and nature management, and related problems and solutions for assessing the public health risk. The prospects of creating methods for rapid assessment of public health risk using modern data and representations of toxicokinetics and toxicodynamics of the substance are substantiated. It is shown that it is possible to deduce adequate mathematical dependencies for substances regardless of their structure, based on modern concepts of the formation of the dose of a toxicant in the body from the position of toxicokinetics. For an adequate forecast of toxicometric indicators (LD, ED) when constructing mathematical models, it is proposed to use pharmaco- and toxicokinetic parameters estimated within the normal range as independent variables (for medicinal substances – not higher than their therapeutic doses, for the other ones – not higher than their thresholds). Our definitions of the notions of norm, threshold of harmful action and pre-pathological conditions of the body from the position of detoxification of substances are presented. The reference range of the norm for the values of the pharmaco- and toxicokinetic parameters of a substance is justified taking into account individual differences of the organism within the boundary of the standard deviation (±2δ) from the normatively established value, which does not lead to any negative (side) physiological deviations.