利用壳聚糖作为抗哮喘药物茶碱的有效载体

IF 1.1 4区工程技术 Q4 POLYMER SCIENCE

Polimery Pub Date : 2023-05-17 DOI:10.14314/polimery.2023.3.4

Noor Firas Aziz, S. Hussein-Al-Ali, M. M. Ghareeb, N. A. Nashwan

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引用次数: 0

摘要

为了解决给药频繁的问题，提高给药效果，将茶碱(THP)沉积在壳聚糖纳米颗粒(csnp)上。制备了50、75、100或150 mg壳聚糖(CS)和25、50、75、100或200 mg三聚磷酸(TPP) (pH分别为4.0、5.0、6.0和6.5)的THP- csnp纳米复合材料，THP质量为100 mg。采用x射线衍射(PXRD)、场发射扫描电镜(FE-SEM)和傅里叶变换红外光谱(FTIR)对纳米复合材料进行了表征。同时测定了药物释放速度。使用Minitab 18程序对结果进行分析。自变量为CS、TPP和pH，因变量为负载效率、zeta电位和粒径。纳米复合材料成功地运输和保护了药物，提供了药物的持续释放。

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The use of chitosan as an effective carrier of theophylline - an anti-asthmatic drug

In order to solve the problem of frequent drug dosing and increase its effectiveness, theophylline (THP) was deposited on chitosan nanoparticles (CSNPs). THP-CSNPs nanocomposites with the composition of 50, 75, 100 or 150 mg of chitosan (CS) and 25, 50, 75, 100 or 200 mg of tripolyphosphate (TPP) at pH 4.0, 5.0, 6.0 and 6.5 were prepared, and a constant weight of THP of 100 mg. The nanocomposites were characterized by X-ray diffraction (PXRD), field emission scanning electron microscopy (FE-SEM), and Fourier transform infrared spectroscopy (FTIR). The rate of drug release was also tested. The Minitab 18 program was used to analyze the results. The independent variables were the CS, TPP, and pH, while loading efficiency, zeta potential, and particle size were the dependent variables. The nanocomposites successfully transported and protected the drug, providing its sustained release.

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来源期刊

Polimery Materials Science-Polymers and Plastics

CiteScore

2.90

自引率

6.20%

发文量

审稿时长

1 months

期刊介绍： The "Polimery" journal, of international circulation, is publishing peerreviewed scientific and technical research papers covering polymer science and technology in the field of polymers, rubbers, chemical fibres and paints. The range of topics covered are raw materials, polymer synthesis, processing and applications of polymers. Apart from scientific and technical research papers the monthly includes technical and commercial information such as reports from fairs and exhibitions as well as home, world and technical news. “Polimery "- an international journal covering the following topics: polymers, rubber, chemical fibres and paints. The Journal is addressed to scientists, managers and engineering staff of universities, Polish Academy of Sciences, R&D institutions, industry, specializing in polymer chemistry, physical chemistry, technology and processing. “Polimery” publishes original, reviewed research, scientific and technology papers in the field of polymer synthesis, analysis, technology and modification, processing, properties, applications and recycling.