保加利亚随机血液样本中乙型肝炎患病率-单站点经验

Q4 Medicine

Acta Medica Bulgarica Pub Date : 2023-05-14 DOI:10.2478/amb-2023-0013

A. Gotseva, E. Naseva

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引用次数: 0

摘要

乙型肝炎表面抗原(HBsAg)在一般人群中的流行程度通常用来估计全球乙型肝炎感染的分布。乙型肝炎核心抗原总抗体(抗- hbc)是证明既往HBV暴露最重要的诊断标记。目的本研究的目的是确定保加利亚人口中乙型肝炎病毒(HBV)感染的流行程度。需要可靠的流行病学数据来估计乙型肝炎的流行率，以确定感染的实际负担并计划预防和控制措施。材料与方法2018-2019年对2140份血清样本进行HBV主要血清学标志物(HBsAg和anti-HBc)检测。结果在HBsAg阴性人群中，HBsAg阳性率为中等水平(5.1%)，抗- hbc阳性率为高水平(27%)。总而言之，在保加利亚普及乙肝疫苗接种(1992年)之前出生的人的乙肝患病率要高得多。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Prevalence of Hepatitis B in Random Bulgarian Blood Samples – A Single-Site Experience

Abstract The worldwide distribution of the HBV infection has usually been estimated by the prevalence of hepatitis B surface antigen (HBsAg) among the general population. Total antibodies for hepatitis B core antigen (anti-HBc) are the most important diagnostic marker for proving prior exposure to HBV. Aim The aim of this study was to determine the prevalence of Hepatitis B virus (HBV) infection among Bulgarian population. Reliable epidemiologic data is needed to estimate the prevalence of Hepatitis B in order to determine the actual burden of the infection and to plan prevention and control measures. Materials and methods A total of 2140 serum samples were tested for major serological markers of HBV (HBsAg and anti-HBc) for a period of two years (2018-2019). Results We established an intermediate prevalence of HBsAg (5.1%) and high prevalence of anti-HBc (27%) among HBsAg negative individuals. Conclusion In conclusion, the prevalence of Hepatitis B is much higher among those born before the introduction of universal hepatitis B vaccination in Bulgaria (1992).

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来源期刊

Acta Medica Bulgarica Medicine-Medicine (all)

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

25 weeks

期刊介绍： About 30 years ago - in 1973, on the initiative of the Publishing House „Medicine and Physical Culture", namely its former director Mr. Traian Ivanov, the Ministry of Health set up and accepted to subsidize a new medical magazine that was to be published only in the English language and had to reflect the status and the achievements of the Bulgarian medical science. Thus the language barrier was overcome and stable relations were established with the international medical society, large libraries, and university centers. The famous internationally known scientist professor Assen A. Hadjiolov was elected edition-in-chief by the first editorial staff and the magazine was named Acta Medica Bulgarica.