柚子汁-药物相互作用:警告

Greeshma K. Shetty, P. Girish, K. Rao, A. Menon
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引用次数: 0

摘要

本文的主要目的是研究某些常用药物与柚子汁的相互作用,柚子汁在印度某些地区通常被视为容易获得的水果或果汁。通过搜索PubMed和网络上的其他文章来确定相关文献。使用的各种搜索词是“葡萄柚”、“柚子”、“药物相互作用”和“果汁-药物相互作用”。纳入标准包括葡萄柚汁与药物相互作用研究和柚子汁与药物相互作用研究。排除标准是与果汁-药物相互作用主题无关的文章。在审查了每篇文章的摘要后,很少有文章因为实际上不相关的主题而被直接排除。最后选取了8篇文章作为参考文献,获得了一定的数据,并在本文中提出了我们的观点。每篇纳入的文章的全文都经过严格审查,并通过数据解释总结出有价值的信息。柚子(Citrus maxima/Citrus grandis)是芦桃科中最大的柑橘类水果,也是葡萄柚的主要祖先。它是一种天然的非杂交柑橘类水果,原产于东南亚。在整个东南亚,柚子通常被用于节日场合。人们还发现它与葡萄柚有类似的药物相互作用。果实大,直径15-25厘米,重1-2公斤。它的外皮比葡萄柚厚,分为11-18个部分。柚子与葡萄柚有着密切的关系,被广泛研究,它含有呋喃香豆素,在体外被鉴定为葡萄柚汁中细胞色素P450 3A4的抑制剂。1750年,格里菲斯·休斯首次描述了这种水果,1789年,帕特里克·布朗将其称为“禁果”或“小柚子”。它的味道也从酸、苦到甜。果实近圆形或略呈梨形,呈串状,类似葡萄,10-15厘米宽,果皮光滑,细点,厚达1厘米。果肉黄色或粉红色至红色,有11-14节,膜薄。这水果多汁。果实呈尖状,种子长约1.25厘米。在卡纳塔克邦,一种名为Devanahalli柚子(Gi注册)的柚子专门生长在班加罗尔Devanahalli taluk周围地区,作为一种外来作物品种。它在当地被称为chakkota。此外,柚子有许多名字,如孟加拉语的batabi lebu或jambura,以及印度语国家的chakotra。在目前的大流行爆发中,城市居民对包装果汁的家庭消费有所增加,而农村居民对容易种植和容易获得的水果(如柚子、葡萄、苹果及其果汁)的家庭消费有所增加。因此,在服用某些药物的柚子汁(类似于葡萄柚汁)时需要谨慎。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pomelo juice–Drug interactions: A word of caution
The main of this article is to study the interactions of certain commonly used drugs with pomelo juice which is commonly consumed as easily available fruit or fruit juice in certain parts of India. Relevant literature was identified by searching PubMed and other articles on the web. Various search words which were used are “Grapefruit,” “pomelo,” “drug interactions,” and “juice-drug interactions.” Inclusion criteria included grapefruit juice–drug interaction studies and pomelo juice–drug interactions. Exclusion criteria were articles actually irrelevant to the juice–drug interaction topics. After reviewing the summary of each article, few articles were directly excluded because of actually irrelevant topics. Finally, eight articles were selected as reference articles and certain data were obtained and our opinion about the same is mentioned in the present article. The full text of each included article was critically reviewed, and valuable information was summarized by data interpretation. Pomelo “(Citrus maxima/Citrus grandis)” is the largest citrus fruit from the family Rutaceae and the principal ancestor of the grapefruit. It is a natural, nonhybrid citrus fruit native to Southeast Asia. Pomelo is commonly consumed and used for festive occasions throughout Southeast Asia. It has also been found to have drug interactions similar to grapefruit. The fruit is large, 15–25 cm in diameter, and weighing 1–2 kg. It has a thicker rind than the grapefruit and is divided into 11–18 segments. Pomelo is closely related to grapefruit and extensively studied and contains furanocoumarins which have been identified as inhibitors of cytochrome P450 3A4 in grapefruit juice in vitro. The fruit was first described in 1750 by Griffith Hughes, and in 1789, Patrick Browne referred to it as “forbidden fruit” or “smaller shaddock.” Its taste also varies from sour or bitter to sweet. The fruit is nearly round or slightly pear shaped in clusters similar to grapes, 10–15 cm wide with smooth, finely dotted peel, up to 1 cm thick. The pulp is yellow or pink to red, which has 11–14 segments with thin membrane. The fruit is very juicy. The fruit presents with pointed seeds about 1.25 cm in length. In Karnataka, a type of pomelo named Devanahalli pomelo (Gi registered) is exclusively grown in the region around Devanahalli taluk, Bangalore, as an exotic crop variety. It is locally known as chakkota. Besides, pomelo has many names such as batabi lebu or jambura in Bengali and chakotra in Hindi-speaking states. In the present pandemic outbreak, in-home consumption of packaged fruit juices has increased among people in the cities, whereas in-home consumption of easily grown and easily available fruits such as pomelo, grapes, apples, and their juices has increased among people in the villages. Hence, caution is required while consuming pomelo juice (similar to grapefruit juice) with certain drugs.
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