伊朗成人非酒精性脂肪性肝病的危险因素:系统回顾和荟萃分析

IF 0.3 4区医学 Q4 GASTROENTEROLOGY & HEPATOLOGY

Hepatitis Monthly Pub Date : 2023-03-12 DOI:10.5812/hepatmon-131523

Ehsan Amini-Salehi, Soheil Hassanipour, F. Joukar, Amirali Daryagasht, M. Khosousi, Maryam Sadat Aleali, M. Ansar, Forough Heidarzad, E. Abdzadeh, Azin Vakilpour, F. Mansour-Ghanaei

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引用次数: 4

摘要

背景:非酒精性脂肪性肝病(NAFLD)在世界范围内进展显著。识别NAFLD的危险因素是预防其发展的关键一步。方法:2022年11月，两名独立研究人员研究了PubMed、ISI/WoS、ProQuest、Scopus、SID、Magiran和谷歌Scholar等7个数据库，以及相关文章的参考文献列表，检索了评估伊朗成年人群NAFLD危险因素的研究。采用Cochran检验评估各研究间的异质性，采用I2统计量组成。观察异质性时采用随机效应模型;否则，采用固定效应模型。采用Egger’s回归检验和Trim-and-Fill分析评估发表偏倚。本研究采用综合meta分析软件(version 3)进行分析。结果:这项研究的结果显示显著的非酒精性脂肪肝与年龄之间的关联(n = 15,比值比(或)= 2.12,95%置信区间CI: 1.79 - 2.51),身体质量指数(n = 46岁或= 5.00,95%置信区间CI: 3.34 - 7.49),腰围(n = 20,或者= 6.37,95%置信区间CI: 3.25 - 12.48)、腰臀比(n = 17日或= 4.72,95%置信区间CI: 3.93 - 5.66)、总胆固醇(n = 39 = 1.80, 95%置信区间CI: 1.52 - 2.13),高密度脂蛋白(n = 37岁或= 0.53,95%置信区间CI:0.44 - 0.65),低密度脂蛋白(n = 31日或= 1.68,95%置信区间CI: 1.38 - 2.05),甘油三酸酯(n = 31日或= 3.21,95%置信区间CI: 2.67 - 3.87)、丙氨酸转氨酶(n = 26日或= 4.06,95%置信区间CI: 2.94 - 5.62)、天冬氨酸转氨酶(n = 27日或= 2.16,95%置信区间CI: 1.50 - 3.12)、高血压(n = 13,或= 2.53,95%置信区间CI: 2.32 - 2.77),收缩压(n = 13,或= 1.83,95%置信区间CI: 1.53 - 2.18),舒张压(n = 14日或= 1.80,95%置信区间CI:1.48 - 2.20)、空腹血糖(n = 31,OR = 2.91, 95% CI: 2.11- 4.01)、胰岛素抵抗的稳态模型评估(n = 5, OR = 1.92, 95% CI: 1.48 - 2.59)、糖尿病(n = 15, OR = 3.04, 95% CI: 2.46 - 3.75)、代谢综合征(n = 10, OR = 3.56, 95% CI: 2.79 - 4.55)和身体活动(n = 11, OR = 0.32, 95% CI: 0.24 - 0.43) (P < 0.05)。结论:总之，有几个因素与NAFLD显著相关。然而，人体测量指数与伊朗成年人群NAFLD的关系最强。

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Risk Factors of Non-alcoholic Fatty Liver Disease in the Iranian Adult Population: A Systematic Review and Meta-analysis

Context: Non-alcoholic fatty liver disease (NAFLD) is progressing considerably worldwide. Identifying the risk factors of NAFLD is a critical step in preventing its progression. Methods: In November 2022, two independent researchers studied seven databases, including PubMed, ISI/WoS, ProQuest, Scopus, SID, Magiran, and Google Scholar, and reference list of relevant articles, searching studies that assessed NAFLD risk factors in the Iranian adult population. Heterogeneity between studies was assessed by Cochran’s test and its composition using I2 statistics. A random-effects model was used when heterogeneity was observed; otherwise, a fixed-effects model was applied. Egger’s regression test and Trim-and-Fill analysis were used to assess publication bias. Comprehensive Meta-analysis software (version 3) was used for the analyses of the present study. Results: The results of this study showed significant associations between NAFLD with age [n = 15, odds ratio (OR) = 2.12, 95% CI: 1.79 - 2.51], body mass index (n = 46, OR = 5.00, 95% CI: 3.34 - 7.49), waist circumference (n = 20, OR = 6.37, 95% CI: 3.25 - 12.48), waist-to-hip ratio (n = 17, OR = 4.72, 95% CI: 3.93 - 5.66), total cholesterol (n = 39, OR = 1.80, 95% CI: 1.52 - 2.13), high-density lipoprotein (n = 37, OR = 0.53, 95% CI: 0.44 - 0.65), low-density lipoprotein (n = 31, OR = 1.68, 95% CI: 1.38 - 2.05), triglyceride (n = 31, OR = 3.21, 95% CI: 2.67 - 3.87), alanine aminotransferase (n = 26, OR = 4.06, 95% CI: 2.94 - 5.62), aspartate aminotransferase (n = 27, OR = 2.16, 95% CI: 1.50 - 3.12), hypertension (n = 13, OR = 2.53, 95% CI: 2.32 - 2.77), systolic blood pressure (n = 13, OR = 1.83, 95% CI: 1.53 - 2.18), diastolic blood pressure (n = 14, OR = 1.80, 95% CI: 1.48 - 2.20), fasting blood sugar (n = 31,OR = 2.91, 95% CI: 2.11- 4.01), homeostatic model assessment for insulin resistance (n = 5, OR = 1.92, 95% CI: 1.48 - 2.59), diabetes mellitus (n = 15, OR = 3.04, 95% CI: 2.46 - 3.75), metabolic syndrome (n = 10, OR = 3.56, 95% CI: 2.79 - 4.55), and physical activity (n = 11, OR = 0.32, 95% CI: 0.24 - 0.43) (P < 0.05). Conclusions: In conclusion, several factors are significantly associated with NAFLD. However, anthropometric indices had the strongest relationship with NAFLD in the Iranian adult population.

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来源期刊

Hepatitis Monthly 医学-胃肠肝病学

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Hepatitis Monthly is a clinical journal which is informative to all practitioners like gastroenterologists, hepatologists and infectious disease specialists and internists. This authoritative clinical journal was founded by Professor Seyed-Moayed Alavian in 2002. The Journal context is devoted to the particular compilation of the latest worldwide and interdisciplinary approach and findings including original manuscripts, meta-analyses and reviews, health economic papers, debates and consensus statements of the clinical relevance of hepatological field especially liver diseases. In addition, consensus evidential reports not only highlight the new observations, original research, and results accompanied by innovative treatments and all the other relevant topics but also include highlighting disease mechanisms or important clinical observations and letters on articles published in the journal.