基于DNA偶极特性和表观遗传学的ECT（电惊厥治疗）可能的假设作用模式

Q4 Medicine

Acta Medica Bulgarica Pub Date : 2021-11-01 DOI:10.2478/amb-2021-0049

H. Koch

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引用次数: 0

摘要

人类基因组由大约23000个基因组成，这些基因无法解释蛋白质或行为的巨大多样性。第二种表观遗传密码保证了基因表达的适应性变异。这种变异的基本原理是DNA或组蛋白的甲基化、乙酰化或磷酸化等转移反应，包括通过电休克疗法(ECT)改变的逆反应。自20世纪30年代以来，这种方法已被成功地应用，但其潜在的分子作用机制尚未阐明。本文讨论了表观遗传基因表达作为一种适应性过程的理论参与，以解释电痉挛治疗后的生化变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Possible Hypothetical Mode of Action of ECT (Electroconvulsive Therapy) Based on DNA Dipole Character and Epigenetics

Abstract The human genome consists of roughly 23000 genes which cannot explain the enormous diversity of proteins or behavior. A second epigenetic code warrants adaptive variation of gene expression. The rationale of this variation are transfer reactions such as methylation, acetylation or phosphorylation of DNA or histones including reverse reactions which are supposed to be altered by electroconvulsive therapy (ECT). The method has been successfully used since the 1930ies but the underlying molecular mechanism of action has not been elucidated yet. The paper discusses the theoretical involvement of epigenetic gene expression as an adaptive process to explain biochemical changes after ECT administration.

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来源期刊

Acta Medica Bulgarica Medicine-Medicine (all)

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

25 weeks

期刊介绍： About 30 years ago - in 1973, on the initiative of the Publishing House „Medicine and Physical Culture", namely its former director Mr. Traian Ivanov, the Ministry of Health set up and accepted to subsidize a new medical magazine that was to be published only in the English language and had to reflect the status and the achievements of the Bulgarian medical science. Thus the language barrier was overcome and stable relations were established with the international medical society, large libraries, and university centers. The famous internationally known scientist professor Assen A. Hadjiolov was elected edition-in-chief by the first editorial staff and the magazine was named Acta Medica Bulgarica.