血细胞计数和血细胞比率作为非特异性重度抑郁症的生物标志物

M. Krivosova, P. Kusnir, M. Kertys, M. Mestanik, I. Tonhajzerova, I. Hrtanek, I. Ondrejka, J. Mokrý
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引用次数: 2

摘要

摘要简介:随着重度抑郁症(MDD)在人群中的患病率不断上升,人们对寻找一种适合该疾病诊断和预后的生物标志物特别感兴趣。许多研究表明,重度抑郁症与系统性炎症过程有关,因此血液元素计数和比率被认为是疾病治疗管理和有效性的有希望的指标。这项回顾性研究的目的是比较绝对和相对白细胞计数,并寻找患者治疗前后它们的比率的变化。方法:我们的研究纳入了36例接受标准治疗方案的MDD新诊断或复发的住院患者。在入院和出院时采集外周血样本。比较患者住院前后(14 ~ 29 d)白细胞绝对计数、中性粒细胞、淋巴细胞、单核细胞、血小板计数及平均血小板体积、红细胞分布宽度、中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值、单核细胞/淋巴细胞比值。进行正态性检验,因此采用单t检验或Mann-Whitney u检验进行数据分析。结果:两组患者住院前后及适当治疗前后血液中各血细胞比例差异无统计学意义。出院后MDD患者单核细胞计数明显增高(p=0.007),出院后MDD复发患者(F.33)与新诊断的MDD患者(F.32)差异显著(p=0.010)。在接受文拉法辛治疗的患者中(N=23),在住院结束时观察到单核细胞/淋巴细胞比率显著增加(p=0.018)。结论:MDD患者的药物治疗和附加治疗仅导致轻微的血细胞计数变化。由于本研究纳入的患者数量较少,且治疗时间较短,比较的是血细胞参数和比值,最终结论还需要进一步细致的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Blood Cell Counts and Blood Cell Ratios as Non-Specific Major Depressive Disorder Biomarkers
Abstract Introduction: With an increasing prevalence of major depressive disorder (MDD) in population there is a particular interest in finding a suitable biomarker for diagnosis and prognosis of the disease. Many studies have shown that MDD is linked to a systemic inflammatory process, so blood elements counts and ratios have been suggested to be promising indicators in the management and effectiveness of the disease therapy. The aim of this retrospective study was to compare absolute and relative white blood cells counts and to search for any changes in their ratios before and after the therapy of the patients. Methods: Our study included 36 patients who were admitted to hospital with either a new diagnosis or a recurrent episode of MDD and who were treated by a standard protocol. The peripheral blood samples were collected both at admission and at hospital discharge. Absolute white blood cell count and counts of neutrophils, lymphocytes, monocytes, platelets, as well as mean platelet volume, red blood cell distribution width, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and monocyte/lymphocyte ratio before and after hospitalization (14–29 days) were evaluated and compared. The test of normality was performed and, accordingly, single t-test or Mann-Whitney U-test was used for data analysis. Results: There were no significant differences between any blood cell ratios in blood samples before and after stay in hospital and appropriate treatment. Monocyte count was significantly higher in MDD patients after hospital discharge (p=0.007), there was a significantly higher difference in discharged patients suffering from MDD recurrent episode (F.33) compared to newly diagnosed MDD (F.32) patients (p=0.010). In patients treated with venlafaxine (N=23) there was a significant increase in monocyte/lymphocyte ratio observed at the end of hospitalization (p=0.018). Conclusions: The pharmacotherapy and additive treatment of the patients suffering from MDD led only to mild changes in blood cells counts. As our study included only a small number of patients, and blood cell parameters and ratios were compared after a relatively short duration of treatment, further and more detailed research is needed for final conclusions.
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来源期刊
自引率
0.00%
发文量
11
审稿时长
14 weeks
期刊介绍: Acta Medica Martiniana is a medical scientific journal, first published in print form in December 2001. It is a continuation of the journal / almanac Folia Medica Martiniana (1971 - 1996). The journal‘s owner is the Jessenius Faculty of Medicine, Comenius University, Slovakia. Dissemination of research results and scientific knowledge from all areas of medicine and nursing. Stimulation, facilitation and supporting of publication activity for the young medical research and clinical generation. The contributions of young novice authors (PhD students and post-doctorials) are particularly welcome. Acta Medica Martiniana is an open-access journal, with a periodicity of publishing three times per year (Apr/Aug/Dec). It covers a wide range of basic medical disciplines, such as anatomy, histology, biochemistry, human physiology, pharmacology, etc., as well as all clinical areas incl. preventive medicine, public health and nursing. Interdisciplinary and multidisciplinary manuscripts, including papers from all areas of biomedical research, are welcome.
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