P. Shoa, I. Abedi, M. Tavakoli, A. Amouheidari, K. Jabbari
{"title":"髓母细胞瘤患儿颅脊髓三维适形放疗后视觉系统并发症发生率的评估","authors":"P. Shoa, I. Abedi, M. Tavakoli, A. Amouheidari, K. Jabbari","doi":"10.18869/ACADPUB.IJRR.18.1.117","DOIUrl":null,"url":null,"abstract":"Background: The use of radiation therapy for medulloblastoma can affect children’s visual system. We estimated children’s visual system complication probability in the craniospinal irradiation (CSI) technique with threedimensional conformal radiotherapy (3D-CRT). Materials and Methods: CSI of fifteen medulloblastoma patients and a phantom were planned with 6 MV photon beams and 23.4 Gy prescribed dose. The doses of lenses were measured using thermoluminescence dosimeters (TLD). The delivered doses and complication probabilities were calculated based on the equivalent uniform dose (EUD) model to each contoured organ, including the bilateral lenses, optic nerves, retinas and optic chiasm. Results: The received dose for each organ was less than the tolerance value (p<0.001), except for the eye lens. The normal tissue complication probability (NTCP) values for all of the organs at risk (OAR) were found insignificant. The discrepancies of calculated and measured doses for the right and left lenses were 6.35% and 6.23% (p<0.001), respectively. Conclusion: The results of this study showed based on the International Commission on Radiological Protection (ICRP) publication 118 that children with medulloblastoma cancer treated with CSI with 3D-CRT method are susceptible to cataract complication.","PeriodicalId":14498,"journal":{"name":"Iranian Journal of Radiation Research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Estimation of the visual system complication probability on children with Medulloblastoma after Craniospinal irradiation with three-dimensional conformal radiotherapy\",\"authors\":\"P. Shoa, I. Abedi, M. Tavakoli, A. Amouheidari, K. Jabbari\",\"doi\":\"10.18869/ACADPUB.IJRR.18.1.117\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: The use of radiation therapy for medulloblastoma can affect children’s visual system. We estimated children’s visual system complication probability in the craniospinal irradiation (CSI) technique with threedimensional conformal radiotherapy (3D-CRT). Materials and Methods: CSI of fifteen medulloblastoma patients and a phantom were planned with 6 MV photon beams and 23.4 Gy prescribed dose. The doses of lenses were measured using thermoluminescence dosimeters (TLD). The delivered doses and complication probabilities were calculated based on the equivalent uniform dose (EUD) model to each contoured organ, including the bilateral lenses, optic nerves, retinas and optic chiasm. Results: The received dose for each organ was less than the tolerance value (p<0.001), except for the eye lens. The normal tissue complication probability (NTCP) values for all of the organs at risk (OAR) were found insignificant. The discrepancies of calculated and measured doses for the right and left lenses were 6.35% and 6.23% (p<0.001), respectively. Conclusion: The results of this study showed based on the International Commission on Radiological Protection (ICRP) publication 118 that children with medulloblastoma cancer treated with CSI with 3D-CRT method are susceptible to cataract complication.\",\"PeriodicalId\":14498,\"journal\":{\"name\":\"Iranian Journal of Radiation Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Journal of Radiation Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18869/ACADPUB.IJRR.18.1.117\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Health Professions\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Radiation Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18869/ACADPUB.IJRR.18.1.117","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Health Professions","Score":null,"Total":0}
Estimation of the visual system complication probability on children with Medulloblastoma after Craniospinal irradiation with three-dimensional conformal radiotherapy
Background: The use of radiation therapy for medulloblastoma can affect children’s visual system. We estimated children’s visual system complication probability in the craniospinal irradiation (CSI) technique with threedimensional conformal radiotherapy (3D-CRT). Materials and Methods: CSI of fifteen medulloblastoma patients and a phantom were planned with 6 MV photon beams and 23.4 Gy prescribed dose. The doses of lenses were measured using thermoluminescence dosimeters (TLD). The delivered doses and complication probabilities were calculated based on the equivalent uniform dose (EUD) model to each contoured organ, including the bilateral lenses, optic nerves, retinas and optic chiasm. Results: The received dose for each organ was less than the tolerance value (p<0.001), except for the eye lens. The normal tissue complication probability (NTCP) values for all of the organs at risk (OAR) were found insignificant. The discrepancies of calculated and measured doses for the right and left lenses were 6.35% and 6.23% (p<0.001), respectively. Conclusion: The results of this study showed based on the International Commission on Radiological Protection (ICRP) publication 118 that children with medulloblastoma cancer treated with CSI with 3D-CRT method are susceptible to cataract complication.
期刊介绍:
Iranian Journal of Radiation Research (IJRR) publishes original scientific research and clinical investigations related to radiation oncology, radiation biology, and Medical and health physics. The clinical studies submitted for publication include experimental studies of combined modality treatment, especially chemoradiotherapy approaches, and relevant innovations in hyperthermia, brachytherapy, high LET irradiation, nuclear medicine, dosimetry, tumor imaging, radiation treatment planning, radiosensitizers, and radioprotectors. All manuscripts must pass stringent peer-review and only papers that are rated of high scientific quality are accepted.