血浆组蛋白去乙酰化酶活性、血脂和糖化血红蛋白水平作为2型糖尿病血糖控制的指标

Q4 Medicine
W. Olooto, Monisola A Ayodele, Joseph O Soola, Hammed A Adenusi, Frank E Agidingbi
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引用次数: 0

摘要

背景:糖尿病(DM)患者的数量在全球范围内稳步上升,其社会经济影响超出了个人,影响到他们的家庭和整个社会。目的:本研究旨在检测2型糖尿病患者的血脂、糖化血红蛋白(HbA1C)和组蛋白去乙酰化酶(HDAC)活性作为血糖控制的指标。方法:招募新诊断的糖尿病患者100例,对照组50例。测量每位参与者的体重、身高、体重指数(BMI)、腰围(WC)和血压。采用标准方法测定空腹血糖(FPG)、甘油三酯、总胆固醇(TC)、高密度脂蛋白(HDLC)和HDAC活性。计算低密度脂蛋白(LDLC)。结果:平均年龄、FPG、收缩压和舒张压、HbA1c、总胆固醇、甘油三酯、低密度脂蛋白和HDAC活性显著增加;与对照组相比,糖尿病患者的血浆HDLC有所下降。HDAC活性与糖尿病患者FPG、WC和病程存在直接且显著的相关性;HbA1C与FBG、TC、ldl、HDLC和糖尿病病程之间的关系;HDAC与HbA1C、HDLC存在直接但不显著的相关性;BMI与TC、甘油三酯和ldl呈显著负相关。结论:通过本研究可以推断血浆HDAC活性与FPGÂ有直接关系,因为HDAC活性随着FPG的升高而升高,提示其可能在代谢中起作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Plasma Histone Deacetylase activities, Lipid Profile, and Glycated Haemoglobin levels as indicator of Glycemic control in Type 2 Diabetes Mellitus
Background: The number of people with Diabetes mellitus (DM) is steadily rising globally and its socio-economic effects extend beyond the individual to affect their families and whole societies.Aim: This study aimed at determining the Plasma Lipid Profile, Glycated Haemoglobin (HbA1C) and Histone Deacetylase (HDAC) enzyme activities as indicator of Glycaemic control in Type 2 Diabetes mellitus.Methods: A total of 100 newly diagnosed DM patients and 50 control subjects were recruited. The weight, height, body mass index (BMI), waist circumference (WC), and blood pressure of each participant were determined. Also, fasting plasma glucose (FPG), triglycerides, total Cholesterol (TC), high density lipoprotein (HDLC) and HDAC activities were measured using standard methods. Low density lipoprotein (LDLC) was computed.Results: A significant increase in mean age, FPG, systolic and diastolic blood pressure, HbA1c total cholesterol, triglyceride, and low density lipoprotein, and HDAC activities; and a decrease in plasma HDLC were observed among the diabetics when compared with the controls. A direct but significant correlation existed between HDAC activities and FPG, WC, and duration of diabetes; and between HbA1C and FBG, TC, LDLC, HDLC, and duration of diabetes; a direct but non-significant correlation existed between HDAC and HbA1C, HDLC; an inverse and significant correlation existed between BMI and TC, Triglyceride and LDLC.Conclusion: It could be inferred from thia study that plasma HDAC activities is directly related to FPG  as it was found to increase with increasing FPG, indicating its likely role in metabolism.
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Acta Medica Saliniana
Acta Medica Saliniana Medicine-Medicine (all)
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