乙酰氧基dmu负载羧甲基壳聚糖纳米胶囊的制备、体外释放评价及分析方法学验证

IF 1.6 4区材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY

Soft Materials Pub Date : 2021-10-19 DOI:10.1080/1539445X.2021.1992426

Joslaine Jacumazo, C. C. Perez, N. Khalil, C. Almeida

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引用次数: 0

摘要

与白藜芦醇相比，乙酰氧基DMU (Ac.DMU - 1,2,3-三甲氧基-5-(4-乙酰氧基苯基)苯)具有更好的药动学性质，是一种潜在的新药。采用Ac.DMU和羧甲基壳聚糖(CMCh)聚合物进行纳米胶囊化是提高药物在人体内生物利用度的一种很有前景的方法。采用乳液溶剂扩散技术制备了不同药聚比的cmc - Ac.DMU纳米胶囊(Ac.DMU-NCs)，包封率分别为69.4%和51.5%，并通过动态光散射、相移电位和红外光谱技术对其进行了表征。体外释放实验表明，nc提高了Ac.DMU的溶解度，使Ac.DMU释放速度快。并根据国际协调会议(International Conference on Harmonization)建议的标准，通过特异性、线性度、检出限和定量限、准确度和精密度分析对方法进行了验证。采用紫外可见光谱法定量测定Ac.DMU，保证了Ac.DMU包封量的可靠结果。结果表明，NCs作为疏水药物Ac.DMU的控释载体具有很大的潜力。图形抽象

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Acetoxy DMU-loaded carboxymethylchitosan nanocapsules: preparation and in vitro release evaluation followed by an analytical methodology validation

ABSTRACT Acetoxy DMU (Ac.DMU – 1,2,3-trimethoxy-5-(4-acetoxystyryl) benzene) is a potential new drug, compared to resveratrol, due to its improved pharmacokinetic properties. Nanoencapsulation using Ac.DMU and carboxymethylchitosan (CMCh) polymer is a promising alternative for improving the bioavailability of drugs in human bodies. Nanocapsules (NCs) based on CMCh with Ac.DMU (Ac.DMU-NCs) by emulsion solvent diffusion technique in different drug-to-polymer ratios have been prepared with encapsulation efficiency of 69.4% and 51.5% and characterized by dynamic light scattering, ζ-potential, and infrared spectroscopy techniques. In vitro release experiments of free Ac.DMU and Ac.DMU-NCs showed an improvement in the solubility of Ac.DMU by NCs, enabling a fast drug release rate. In addition, the method was validated through analyses of specificity, linearity, limit of detection and quantification, accuracy, and precision according to the standards suggested by the International Conference on Harmonization. UV–Vis spectroscopy used to quantify Ac.DMU ensured reliable results for the amount of encapsulated Ac.DMU. The results suggest a promising potential of NCs as carriers of the hydrophobic drug Ac.DMU for controlled release. Graphical abstract

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来源期刊

Soft Materials 工程技术-材料科学：综合

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

2.2 months

期刊介绍： Providing a common forum for all soft matter scientists, Soft Materials covers theory, simulation, and experimental research in this rapidly expanding and interdisciplinary field. As soft materials are often at the heart of modern technologies, soft matter science has implications and applications in many areas ranging from biology to engineering. Unlike many journals which focus primarily on individual classes of materials or particular applications, Soft Materials draw on all physical, chemical, materials science, and biological aspects of soft matter. Featured topics include polymers, biomacromolecules, colloids, membranes, Langmuir-Blodgett films, liquid crystals, granular matter, soft interfaces, complex fluids, surfactants, gels, nanomaterials, self-organization, supramolecular science, molecular recognition, soft glasses, amphiphiles, foams, and active matter. Truly international in scope, Soft Materials contains original research, invited reviews, in-depth technical tutorials, and book reviews.