中老年人血清维生素D与血脂的相关性研究

Q4 Nursing

中华临床营养杂志 Pub Date : 2018-12-30 DOI:10.3760/CMA.J.ISSN.1674-635X.2018.06.003

Wenxia Cui, Haiyan Yang, Fenghui Pan, Hui Wang, Weng Zheng, Man Li

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引用次数: 0

摘要

目的探讨中老年患者血清25-羟基维生素D（25-OH-D）与血脂水平的相关性。方法选择2016年5月至2017年5月在我院住院的284例年龄在40岁以上的患者，根据25-OH-D水平分为四组：正常水平不低于30ng/ml组、轻度缺乏水平在20至29ng/ml组和中度缺乏水平在10至19ng/ml组，严重缺乏组低于10ng/ml。空腹抽血检测肝肾功能、脂质、钙、磷和25-OH-D水平。通过单因素方差分析比较各组之间的脂质水平，并通过Pearson相关性和多元线性回归评估脂质概况与25-OH-D水平之间的相关性。结果严重缺乏组甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和总胆固醇/高密度脂蛋白-胆固醇（TC/HDL-C）水平显著升高，高密度脂蛋白胆固醇≥1.04mmol/L组血清25-OH-D水平显著高于高密度脂素胆固醇<1.04mmol/L组（女性P=0.007，男性P=0.034）多元线性回归分析显示，在调整年龄、BMI、肝肾功能、血清钙和血清磷后，25-OH-D水平与HDL-C呈正相关（女性β=0.259，P=0.047，男性β=0.217，P=0.049），血清25-OH-D水平与HDL-C呈正相关。关键词：25-羟基维生素D；脂质概况；中老年人

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Correlation of serum vitamin D with serum lipid in middle-aged and elderly people

Objective To investigate the correlation of serum 25-hydroxy-vitamin D (25-OH-D) with lipid profiles in middle-aged and elderly patients. Methods A total of 284 patients aged over 40 years and admitted in our hospital from May 2016 to May 2017 were selected and divided into four groups according to 25-OH-D levels as the group of normal level which was not less than 30 ng/ml, the group of slight deficiency which was between 20 and 29 ng/ml, the group of moderate deficiency which was between 10 and 19 ng/ml, and the group of severely deficiency which was under 10 ng/ml. Fasting blood draw were taken to detect liver and renal functions, lipids, calcium, phosphorus and 25-OH-D levels. The level of lipids between groups was compared by one-way ANOVA, and the association between lipid profiles and 25-OH-D levels was assessed by Pearson correlation and multiple linear regression. Results The levels of triglyceride (TG), low density lipoprotein cholesterin (LDL-C) and total cholesterol/high density lipoprotein cholesterol (TC/ HDL-C) were significantly higher and the HDL-C levels were significantly lower in the groups of severely deficiency, moderate deficiency and slight deficiency than in the normal group (P=0.035, P=0.015, P=0.013). The levels of serum 25-OH-D were significantly higher in HDL-C≥1.04 mmol/L group than in HDL-C<1.04 mmol/L group (Female P=0.007, male P=0.034). The correlation analysis showed that serum 25-OH-D level was positively associated with HDL-C (female r=0.309, P=0.002, male r=0.241, P=0.002). The multiple linear regression analysis showed that 25-OH-D level was positively correlated with HDL-C, after adjusting age, BMI, liver and kidney function, serum calcium and serum phosphorus (female β=0.259, P=0.047, male β=0.217, P=0.049). Conclusion The incidence of vitamin D deficiency is high in middle-aged and elderly patients, and the level of serum 25-OH-D is positively correlated with HDL-C. Key words: 25-hydroxy vitamin D; Lipid profiles; Middle-aged and elderly people

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来源期刊

中华临床营养杂志 Nursing-Nutrition and Dietetics

CiteScore

0.20

自引率

0.00%

发文量

2282

期刊介绍： The Chinese Journal of Clinical Nutrition was founded in 1993. It is the first professional academic journal (bimonthly) in my country co-sponsored by the Chinese Medical Association and the Chinese Academy of Medical Sciences to disseminate information on clinical nutrition support, nutrient metabolism, the impact of nutrition support on outcomes and "cost-effectiveness", as well as translational medicine and nutrition research. It is also a professional journal of the Chinese Medical Association's Parenteral and Enteral Nutrition Branch. The purpose of the Chinese Journal of Clinical Nutrition is to promote the rapid dissemination of knowledge on nutrient metabolism and the rational application of parenteral and enteral nutrition, focusing on the combination of multidisciplinary and multi-regional field investigations and clinical research. It mainly reports on nutritional risk screening related to the indications of parenteral and enteral nutrition support, "cost-effectiveness" research on nutritional drugs, consensus on clinical nutrition, guidelines, expert reviews, randomized controlled studies, cohort studies, glycoprotein and other nutrient metabolism research, systematic evaluation of clinical research, evidence-based case reports, special reviews, case reports and clinical experience exchanges, etc., and has a special column on new technologies related to the field of clinical nutrition and their clinical applications.