比较研究分析NFE2L2基因在重金属诱导毒性中的关键作用

IF 1.3 Q4 ENVIRONMENTAL SCIENCES
Prekshi Garg, N. Srivastava, P. Srivastava
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引用次数: 0

摘要

背景:铜、镍、砷、钴和镉等重金属的积累量日益增加。这些重金属的积累对人类健康构成严重威胁。元素毒性百分比已被发现每天都在增加,并产生从组织到基因水平的不同的小问题到大问题。由于这些重金属的污染,不同的重要基因表达发生了改变。本研究旨在确定一种与主要重金属毒性有关的常见靶基因,并研究该基因对相关生物系统的主要影响。方法:在这项工作的进展中,通过严格的数据管理,列出了与铜、镍、砷、钴和镉毒性有关的主要基因,并使用计算机工具STRING和Gene Mania数据库构建了一条显示所有基因相关性和物理相互作用的途径。此外,使用全基因组关联研究(GWAS)、基因型组织表达(GTEx)和RegulomeDB等计算机工具对发现的基因进行了功能和表达分析。结果:根据网络分析,NFE2L2被认为是参与上述重金属毒性的常见靶标。表达分析显示,在食道、卵巢、膀胱、阴道、甲状腺和皮肤组织中观察到NFE2L2的最高表达。通路水平的详细研究表明,在免疫缺陷和发育迟缓中观察到了重要的参与。结论:该研究开辟了一个广阔的视野,即这些毒物的主要靶标是神经生物学痛苦和生物过程的各种途径,因此,它可以被认为是重金属毒性的易感靶标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative investigation to analyse the critical role of NFE2L2 gene in heavy metal induced toxicity through in silico approaches
Background: Accumulation of heavy metals like copper, nickel, arsenic, cobalt, and cadmium are increasing day by day. Accumulation of these heavy metals poses serious threats to human health. Elemental toxicity percentage has been found to be increased day-by-day and creating different minor to major problems from tissue to the gene level. Different important gene expressions are altered due to the contamination of such heavy metals. The present study aimed to identify a common target gene that is involved in the toxicity of major heavy metals and to study the major impact of the gene on the concerned biological system. Methods: In the progression of the work, major genes involved in copper, nickel, arsenic, cobalt, and cadmium toxicity were listed through intense data curation, and a pathway showing the correlation and physical interaction of all the genes that were constructed using in-silico tools STRING and Gene Mania database. Further, functional and expression analysis of the discovered gene was done using in-silico tools like genome-wide association study (GWAS), genotype-tissue expression (GTEx), and RegulomeDB. Results: According to the network analysis, NFE2L2 was recognized as a common target involved in the above-mentioned heavy metals toxicity. Expression analysis revealed that the highest expression of NFE2L2 was observed in tissues of oesophagus, ovary, bladder, vagina, thyroid, and skin. Detailed investigation at the pathway level revealed that the involvement was importantly observed in immunodeficiency and developmental delay. Conclusion: The study opened a wide vision that the major target of such toxicants is various pathways of neurobiological distress and biological processes, and hence, it can be considered as a susceptible target for heavy metals-induced toxicity.
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来源期刊
CiteScore
2.40
自引率
37.50%
发文量
17
审稿时长
12 weeks
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