癌症细胞应激的免疫监测

IF 4.1 Q2 CELL BIOLOGY
Seila Lorenzo-Herrero, Christian Sordo-Bahamonde, Segundo González, Alejandro López-Soto
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引用次数: 0

摘要

癌症的发展受到识别并消除恶性转化细胞的效应免疫反应的严格控制。尽管如此,某些免疫亚群,如肿瘤相关巨噬细胞,已被描述为促进肿瘤生长,揭示了免疫系统在癌症中的双重优势作用。细胞应激可以调节免疫细胞和肿瘤细胞之间的串扰,重塑肿瘤免疫原性和/或免疫功能和表型。浸润免疫细胞暴露于肿瘤微环境中典型存在的具有挑战性的条件。作为回报,在应激条件下激活的无数信号通路可能会将平衡推向刺激抗肿瘤反应或免疫介导的肿瘤进展。在此,我们探讨了细胞应激的不同情况如何影响先天免疫和适应性免疫,以及由此对癌症建立和发展的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunosurveillance of cancer cell stress.

Cancer development is tightly controlled by effector immune responses that recognize and eliminate malignantly transformed cells. Nonetheless, certain immune subsets, such as tumor-associated macrophages, have been described to promote tumor growth, unraveling a double-edge role of the immune system in cancer. Cell stress can modulate the crosstalk between immune cells and tumor cells, reshaping tumor immunogenicity and/or immune function and phenotype. Infiltrating immune cells are exposed to the challenging conditions typically present in the tumor microenvironment. In return, the myriad of signaling pathways activated in response to stress conditions may tip the balance toward stimulation of antitumor responses or immune-mediated tumor progression. Here, we explore how distinct situations of cellular stress influence innate and adaptive immunity and the consequent impact on cancer establishment and progression.

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来源期刊
Cell Stress
Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)
CiteScore
13.50
自引率
0.00%
发文量
21
审稿时长
15 weeks
期刊介绍: Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.
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