心衰患者CORIN的评价:系统回顾和荟萃分析

IF 0.6 4区医学 Q4 IMMUNOLOGY

European Journal of Inflammation Pub Date : 2022-01-01 DOI:10.1177/1721727X221130650

Nianxin Jiang, B. Jiang, Xuan Zhang, W. Yong, S. Zhuang

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引用次数: 0

摘要

目的:我们旨在评估CORIN与心力衰竭之间的关系。方法:本研究使用PubMed、EMBASE、Cochrane数据库和中国知网(CNKI)检索与心衰患者相关的corin相关全文文章。我们绘制了森林图，并根据纳入的数据进行了敏感性和偏倚分析。接下来，我们使用Review Manager 5.2软件来评估所选文章之间的异质性。结果:我们的荟萃分析结果显示，CORIN与心力衰竭(HF)之间存在显著关系。心衰组与对照组CORIN差异有统计学意义(MD = - 293.88, 95%可信区间[-380.26，- 207.49]，p < 0.00001;异质性p < 0.0001, I2= 97%)，缺血组与非缺血组CORIN差异有统计学意义(MD = 88.79, 95%可信区间[70.46107.12]，异质性p < 0.000, p = 0.94, l2= 0%)。在亚组分析中，三种不同的HF水平有显著性差异。观察到有限的发表偏倚，该研究是稳健的。结论:总之，结果表明CORIN与心力衰竭密切相关，可能有助于心力衰竭的诊断。

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Evaluation of CORIN in patients with heart failure: A systematic review and meta-analysis

Objectives: We aim to evaluate the association between CORIN and heart failure. Methods: This study used PubMed, EMBASE, Cochrane database, and China National Knowledge Database (CNKI) to search for CORIN-related full-text articles with heart failure patients. We drew forest plots, performed sensitivity and bias analyses based on the included data. Next, we used Review Manager 5.2 software to assess the heterogeneity among selected articles. Results: Our meta-analysis results showed there was significant relationship between CORIN and heart failure (HF). There was significant difference of CORIN between heart failure group and control group (MD = −293.88, 95% confidence interval [-380.26, −207.49], p < .00001; heterogeneity p < .0001, I2= 97%) and there was significant difference in CORIN between ischemic group and non-ischemic group (MD = 88.79, 95% confidence interval [70.46107.12], heterogeneity p < .000, p = 0.94, l2= 0%). In subgroup analysis, there were significant differences in three different HF levels. Limited publication bias was observed, and this study was robust. Conclusion: In short, the results showed that CORIN was closely related with heart failure and might be helpful in the diagnosis of heart failure.

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来源期刊

European Journal of Inflammation 医学-免疫学

CiteScore

0.90

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： European Journal of Inflammation is a multidisciplinary, peer-reviewed, open access journal covering a wide range of topics in inflammation, including immunology, pathology, pharmacology and related general experimental and clinical research.