I型胶原α1-血小板衍生生长因子β链融合基因在纤维肉瘤转化的皮肤纤维肉瘤隆突发展中的可能作用

IF 1.1 Q4 ALLERGY

Journal of Cutaneous Immunology and Allergy Pub Date : 2023-01-24 DOI:10.1002/cia2.12297

Fuminori Katsumata MD, Koji Kamiya MD, PhD, Hitomi Miyauchi BEng, Hirofumi Okada MD, Atsuko Sato MD, PhD, Takeo Maekawa MD, PhD, Mayumi Komine MD, PhD, Mamitaro Ohtsuki MD, PhD

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引用次数: 0

摘要

伴有纤维肉瘤转化的隆突性皮肤纤维肉瘤(DFSP‐FS)是一种罕见的变体，其复发和转移率高于DFSP。检测I型胶原α 1 (COL1A1) -血小板衍生生长因子β链(PDGFB)融合基因对诊断DFSP有重要意义。在这封信中，我们报告了一例DFSP - FS，重点关注COL1A1 - PDGFB融合基因在病变中的表达。COL1A1 - PDGFB融合基因的表达增加可能与DFSP发病过程中纤维肉瘤的改变有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Possible role of the collagen type I alpha 1–platelet-derived growth factor beta chain fusion gene in the development of dermatofibrosarcoma protuberans with fibrosarcomatous transformation

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Possible role of the collagen type I alpha 1–platelet-derived growth factor beta chain fusion gene in the development of dermatofibrosarcoma protuberans with fibrosarcomatous transformation

Dermatofibrosarcoma protuberans with fibrosarcomatous transformation (DFSP-FS) is a rare variant, with higher rates of recurrence and metastasis than DFSP. Detection of the collagen type I alpha 1 (COL1A1)–platelet-derived growth factor beta chain (PDGFB) fusion gene is useful for the diagnosis of DFSP. In this letter, we report a case of DFSP-FS, focusing on the expression of the COL1A1-PDGFB fusion gene in the lesions. Increased expression of the COL1A1-PDGFB fusion gene may be associated with fibrosarcomatous changes during the pathogenesis of DFSP.

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来源期刊

Journal of Cutaneous Immunology and Allergy Medicine-Dermatology

CiteScore

0.60

自引率

10.00%

发文量

审稿时长

12 weeks