单多态性位点与急性淋巴细胞白血病风险之间的关系

IF 0.8 Q4 GENETICS & HEREDITY

Meta Gene Pub Date : 2022-02-01 DOI:10.1016/j.mgene.2021.101006

Mohammadreza Farrokhi , Hediyeh Rostami , Zahra Simaei , Marziye Bahrebar , Fateme Khoshbin , Niloofar Ataee , Nioosha Ataee , Maryam Ghaedi Heydari , Farzaneh Ahmadi Shapoorabadi , Atefeh Zamani , Nasrin Fattahi Dolatabadi , Hossein Tabatabaeian

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引用次数: 0

摘要

淋巴样祖细胞增殖释放可导致急性淋巴母细胞白血病。这种恶性肿瘤儿童患病率高，成人预后差，早期诊断仍然是一个巨大的挑战。单核苷酸多态性(snp)可以作为一种有效的遗传因子，作为诊断和预后的生物标志物进行研究。虽然已经报道了一些与ALL风险显著相关的snp，但需要更多的研究来完善这些生物标志物的列表，以更好地预测ALL癌症的风险。在这项研究中，我们使用四引物ARMS PCR方法从ALL患者和健康对照中选择了8个snp并进行了基因分型。结果显示，snp位点上不同等位基因的存在可以控制ALL发病的风险。这些snp包括rs10757278、rs1800472、rs12430881、rs35958982、rs1946518、rs4073、rs3813865和rs889312。从这项工作中获得的数据可能对临床有影响。

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The association between single polymorphic positions and the risk of acute lymphoblastic leukemia

The unleased proliferation of lymphoid progenitor cells could result in Acute lymphoblastic leukemia (ALL). The early diagnosis of this malignancy, with high prevalence in children and poor prognosis in adults, has remained a big challenge. Single Nucleotide Polymorphisms (SNPs) could be studied as potent genetic factors to be used as the diagnosis and prognosis biomarkers. Although some SNPs with significant association with the risk of ALL have been reported, more studies are needed to improve the list of these biomarkers to better predict the risk of ALL cancer. In this study, we selected and genotyped eight SNPs in ALL patients and healthy controls using the tetra-primer ARMS PCR method. The outcomes significantly revealed that the presence of different alleles at the SNPs positions could manipulate the risk of ALL incidence. These SNPs include rs10757278, rs1800472, rs12430881, rs35958982, rs1946518, rs4073, rs3813865 and rs889312. The data obtained from this work might have implications in clinics.

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来源期刊

Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.