肝间充质干细胞特性的标记物

A. Lotfy
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引用次数: 1

摘要

间充质干细胞(MSCs)具有自我更新、免疫调节和多能性等特点。由于MSCs具有多系分化潜能,在体内和体外均可诱导分化为脂肪细胞、成骨细胞、软骨细胞、肌肉细胞、神经细胞、肝细胞和胰腺β细胞。这些特性使间充质干细胞在细胞治疗和再生医学中具有很大的应用前景。MSCs最初被描述为来自骨髓的基质干细胞,在培养中具有纺锤形。然而,尽管骨髓被认为是骨髓间充质干细胞的标准来源,但从其他来源分离的骨髓间充质干细胞在表面标记物、增殖率和分化能力方面具有不同的特征[5-7]。骨髓间充质干细胞已从许多其他来源分离出来,如脂肪组织、牙髓、脐带血和羊水[8-10]。肝组织是骨髓间充质干细胞的另一种来源。科学家们已经从不同物种中分离出肝间充质干细胞(LMSCs),并试图对其进行表征,希望这些细胞能够成为骨髓间充质干细胞(BMSCs)的更好替代品,特别是对于肝脏疾病而言。关于间充质干细胞的一个具有挑战性的方面是它们的特征。在这篇综述中,我们将重点介绍不同物种的研究,如人类、小鼠、大鼠、兔子、羊、鸡和牛。人骨髓间充质干细胞和人骨髓间充质干细胞
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Markers for the Characterization of Liver Mesenchymal Stem Cell
Mesenchymal stem cells (MSCs) have the characteristics of self-renewal, immune regulation and multipotency. Due to their multi-lineage differentiation potential [1], MSCs can be induced to differentiate into adipocytes, osteoblasts, chondrocytes, muscle cells, nerve cells, liver cells and pancreatic beta cells in vivo and in vitro. These characteristics make MSCs promising candidates for use in cell therapy and regenerative medicine [24]. MSCs were first described as stromal stem cells from the bone marrow that have a spindle shape in culture. However, although the bone marrow is considered the standard source for MSCs, MSCs isolated from other sources have different features in terms of surface markers, proliferation rates, and differentiation capability [5-7]. MSCs have been isolated from a number of other sources, such as adipose tissue, dental pulp, umbilical cord blood, and amniotic fluid [8-10]. One alternative source for MSCs is liver tissue. Scientists have isolated liver mesenchymal stem cells (LMSCs) from different species and attempted to characterize them in hopes that these cells could be a better alternative to bone marrow mesenchymal stem cells (BMSCs), especially for liver diseases [8]. One of the challenging aspects concerning MSCs in general is their characterization. In this mini-review, we will focus on studies that characterized LMSCs from different species, such as humans, mice, rats, rabbits, sheep, chickens and cattle. Human LMSCs and human BMSCs
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