多酚和抗氧化剂对萘普生固态光降解的光保护作用

Photochem Pub Date : 2022-11-06 DOI:10.3390/photochem2040056
Kohei Kawabata, Ayano Miyoshi, H. Nishi
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引用次数: 3

摘要

光稳定是确保光降解药物质量和数量的重要方法。我们研究的目的是开发一种光稳定剂策略,重点是添加光稳定剂。在本研究中,评估了选定的多酚和抗氧化剂对萘普生(NPX)固态光降解的保护作用。通过高效液相色谱法(HPLC)测定了NPX的残留量,并评价了所测试的添加剂对紫外线(UV)照射诱导的NPX光降解的保护作用。结果,槲皮素、姜黄素和白藜芦醇完全抑制了NPX的光降解。当它们与NPX混合时,与没有添加剂的样品相比,紫外线照射后NPX的残留量显著更高,并且与它们的对照样品相当。此外,为了阐明这些添加剂对NPX光降解的高度保护作用的机制,测定了它们的抗氧化能力和紫外线过滤能力。尽管与NPX相比,光保护添加剂表现出更显著的紫外线吸收,但所选多酚和抗氧化剂的光保护作用与抗氧化能力之间没有相关性。从这些结果中可以清楚地看出,对于固态光降解药物来说,更高的紫外线过滤活性对于更好的光稳定剂是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Photoprotective Effects of Selected Polyphenols and Antioxidants on Naproxen Photodegradability in the Solid-State
Photostabilization is an important methodology to ensure both the quality and quantity of photodegradable pharmaceuticals. The purpose of our study is to develop a photostabilization strategy focused on the addition of photostabilizers. In this study, the protective effects of selected polyphenols and antioxidants on naproxen (NPX) photodegradation in the solid state were evaluated. Residual amounts of NPX were determined by high-performance liquid chromatography (HPLC), and the protective effects of tested additives on NPX photodegradation induced by ultraviolet light (UV) irradiation were evaluated. As a result, quercetin, curcumin, and resveratrol suppressed NPX photodegradation completely. When they were mixed with NPX, the residual amounts of NPX after UV irradiation were significantly higher compared to that without additives, and comparable to those of their control samples. In addition, to clarify the mechanisms of the highly protective effects of these additives on NPX photodegradation, their antioxidative potencies, and UV filtering potencies were determined. There was no correlation between photoprotective effects and antioxidative potencies among selected polyphenols and antioxidants although photoprotective additives showed more significant UV absorption compared to NPX. From these results, it is clarified that a higher UV filtering activity is necessary for a better photostabilizer to photodegradable pharmaceuticals in the solid state.
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CiteScore
3.60
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